Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature
Fibrosis is a common and mostly progressive pathological outcome in various chronic inflammatory disorders. Dermal (skin) fibrosis, which is associated with intense skin lesions, is a result of an uncontrolled healing process in the dermis, particularly disproportionate fibroblast proliferation and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Golestan University of Medical Sciences
2022-05-01
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| Series: | Jorjani Biomedicine Journal |
| Subjects: | |
| Online Access: | http://goums.ac.ir/jorjanijournal/article-1-906-en.html |
| _version_ | 1797986208704364544 |
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| author | Mahmoud Mohammadi Leila Kohan Mohsen Saeidi Marie Saghaeian-Jazi Saeed Mohammadi |
| author_facet | Mahmoud Mohammadi Leila Kohan Mohsen Saeidi Marie Saghaeian-Jazi Saeed Mohammadi |
| author_sort | Mahmoud Mohammadi |
| collection | DOAJ |
| description | Fibrosis is a common and mostly progressive pathological outcome in various chronic inflammatory disorders. Dermal (skin) fibrosis, which is associated with intense skin lesions, is a result of an uncontrolled healing process in the dermis, particularly disproportionate fibroblast proliferation and extracellular matrix (ECM) production. Animal models are substantial tools in biomedical investigations and have been considerably employed to evaluate miscellaneous features of diseases that cannot be demonstrated otherwise in humans. To date, various skin fibrosis models have been generated, including the transgene and/or genetic models and chemical and drug-induced models. However, genetic models are sophisticated and need access to convoluted methods. Accordingly, the introduction of affordable and easy to generate fibrosis models in the skin is crucial. Here, we aimed to introduce the chemical/drug-induced skin fibrosis animal models to provide an updated list of available approaches. |
| first_indexed | 2024-04-11T07:30:22Z |
| format | Article |
| id | doaj.art-f87d5d0649374320902bbdb72c91be44 |
| institution | Directory Open Access Journal |
| issn | 2645-3509 |
| language | English |
| last_indexed | 2024-04-11T07:30:22Z |
| publishDate | 2022-05-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Jorjani Biomedicine Journal |
| spelling | doaj.art-f87d5d0649374320902bbdb72c91be442022-12-22T04:36:56ZengGolestan University of Medical SciencesJorjani Biomedicine Journal2645-35092022-05-011026975Inducible Animal Models of Skin Fibrosis; Updated Review of the LiteratureMahmoud Mohammadi0Leila Kohan1Mohsen Saeidi2Marie Saghaeian-Jazi3Saeed Mohammadi4 Department of biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran. Department of biology, Islamic Azad University, Arsanjan branch, Arsanjan, Iran. Stem Cell Research center, Golestan University of Medical Sciences, Gorgan, Iran. Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran. Stem Cell Research center, Golestan University of Medical Sciences, Gorgan, Iran. Fibrosis is a common and mostly progressive pathological outcome in various chronic inflammatory disorders. Dermal (skin) fibrosis, which is associated with intense skin lesions, is a result of an uncontrolled healing process in the dermis, particularly disproportionate fibroblast proliferation and extracellular matrix (ECM) production. Animal models are substantial tools in biomedical investigations and have been considerably employed to evaluate miscellaneous features of diseases that cannot be demonstrated otherwise in humans. To date, various skin fibrosis models have been generated, including the transgene and/or genetic models and chemical and drug-induced models. However, genetic models are sophisticated and need access to convoluted methods. Accordingly, the introduction of affordable and easy to generate fibrosis models in the skin is crucial. Here, we aimed to introduce the chemical/drug-induced skin fibrosis animal models to provide an updated list of available approaches.http://goums.ac.ir/jorjanijournal/article-1-906-en.htmlfibrosismodelsanimalskinbleomycinhypochlorous acidvinyl chloride |
| spellingShingle | Mahmoud Mohammadi Leila Kohan Mohsen Saeidi Marie Saghaeian-Jazi Saeed Mohammadi Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature Jorjani Biomedicine Journal fibrosis models animal skin bleomycin hypochlorous acid vinyl chloride |
| title | Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature |
| title_full | Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature |
| title_fullStr | Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature |
| title_full_unstemmed | Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature |
| title_short | Inducible Animal Models of Skin Fibrosis; Updated Review of the Literature |
| title_sort | inducible animal models of skin fibrosis updated review of the literature |
| topic | fibrosis models animal skin bleomycin hypochlorous acid vinyl chloride |
| url | http://goums.ac.ir/jorjanijournal/article-1-906-en.html |
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