Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr−/− mice

Neutrophil-specific STAT4 deficiency attenuates atherosclerotic burden and improves plaque stability via reduction in neutrophil activation and recruitment into aortas of Ldlr−/− mice

Background and aimsNeutrophils drive atheroprogression and directly contribute to plaque instability. We recently identified signal transducer and activator of transcription 4 (STAT4) as a critical component for bacterial host defense in neutrophils. The STAT4-dependent functions of neutrophils in a...

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Bibliographic Details
Main Authors: W. Coles Keeter, Alina K. Moriarty, Rachel Akers, Shelby Ma, Marion Mussbacher, Jerry L. Nadler, Elena V. Galkina
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
neutrophils
atherosclerosis
plaque stability
inflammation
immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1175673/full

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