Cellular crosstalk during liver regeneration: unity in diversity
Abstract The liver is unique in its ability to regenerate from a wide range of injuries and diseases. Liver regeneration centers around hepatocyte proliferation and requires the coordinated actions of nonparenchymal cells, including biliary epithelial cells, liver sinusoidal endothelial cells, hepat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-022-00918-z |
| _version_ | 1828437812350812160 |
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| author | Wenzhi Shu Mengfan Yang Jiayin Yang Shengda Lin Xuyong Wei Xiao Xu |
| author_facet | Wenzhi Shu Mengfan Yang Jiayin Yang Shengda Lin Xuyong Wei Xiao Xu |
| author_sort | Wenzhi Shu |
| collection | DOAJ |
| description | Abstract The liver is unique in its ability to regenerate from a wide range of injuries and diseases. Liver regeneration centers around hepatocyte proliferation and requires the coordinated actions of nonparenchymal cells, including biliary epithelial cells, liver sinusoidal endothelial cells, hepatic stellate cells and kupffer cells. Interactions among various hepatocyte and nonparenchymal cells populations constitute a sophisticated regulatory network that restores liver mass and function. In addition, there are two different ways of liver regeneration, self-replication of liver epithelial cells and transdifferentiation between liver epithelial cells. The interactions among cell populations and regenerative microenvironment in the two modes are distinct. Herein, we first review recent advances in the interactions between hepatocytes and surrounding cells and among nonparenchymal cells in the context of liver epithelial cell self-replication. Next, we discuss the crosstalk of several cell types in the context of liver epithelial transdifferentiation, which is also crucial for liver regeneration. Video abstract |
| first_indexed | 2024-12-10T19:52:25Z |
| format | Article |
| id | doaj.art-f87de793669941328017162d61bf3a10 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-10T19:52:25Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-f87de793669941328017162d61bf3a102022-12-22T01:35:45ZengBMCCell Communication and Signaling1478-811X2022-08-0120111310.1186/s12964-022-00918-zCellular crosstalk during liver regeneration: unity in diversityWenzhi Shu0Mengfan Yang1Jiayin Yang2Shengda Lin3Xuyong Wei4Xiao Xu5Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineDepartment of Liver Surgery and Liver Transplantation Center, West China Hospital of Sichuan UniversityKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of MedicineAbstract The liver is unique in its ability to regenerate from a wide range of injuries and diseases. Liver regeneration centers around hepatocyte proliferation and requires the coordinated actions of nonparenchymal cells, including biliary epithelial cells, liver sinusoidal endothelial cells, hepatic stellate cells and kupffer cells. Interactions among various hepatocyte and nonparenchymal cells populations constitute a sophisticated regulatory network that restores liver mass and function. In addition, there are two different ways of liver regeneration, self-replication of liver epithelial cells and transdifferentiation between liver epithelial cells. The interactions among cell populations and regenerative microenvironment in the two modes are distinct. Herein, we first review recent advances in the interactions between hepatocytes and surrounding cells and among nonparenchymal cells in the context of liver epithelial cell self-replication. Next, we discuss the crosstalk of several cell types in the context of liver epithelial transdifferentiation, which is also crucial for liver regeneration. Video abstracthttps://doi.org/10.1186/s12964-022-00918-zLiver regenerationHepatocytesNon-parenchymal cellsLiver progenitor cellsCellular crosstalk |
| spellingShingle | Wenzhi Shu Mengfan Yang Jiayin Yang Shengda Lin Xuyong Wei Xiao Xu Cellular crosstalk during liver regeneration: unity in diversity Cell Communication and Signaling Liver regeneration Hepatocytes Non-parenchymal cells Liver progenitor cells Cellular crosstalk |
| title | Cellular crosstalk during liver regeneration: unity in diversity |
| title_full | Cellular crosstalk during liver regeneration: unity in diversity |
| title_fullStr | Cellular crosstalk during liver regeneration: unity in diversity |
| title_full_unstemmed | Cellular crosstalk during liver regeneration: unity in diversity |
| title_short | Cellular crosstalk during liver regeneration: unity in diversity |
| title_sort | cellular crosstalk during liver regeneration unity in diversity |
| topic | Liver regeneration Hepatocytes Non-parenchymal cells Liver progenitor cells Cellular crosstalk |
| url | https://doi.org/10.1186/s12964-022-00918-z |
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