How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy
During the last decades, a growing number of studies have shown that infections during pregnancy have an important impact on both pregnant women and their fetuses. Our goal was to include newborns from pregnancies with SARS-CoV-2 infection and to investigate the extension of neonatal complications u...
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MDPI AG
2024-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/14/2/224 |
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| author | Daniela Eugenia Popescu Ana Maria Cristina Jura Dana Știube Adrian Ciulpan Florina Stoica Simona Ioana Șipoș Cosmin Cîtu Florin Gorun Mărioara Boia |
| author_facet | Daniela Eugenia Popescu Ana Maria Cristina Jura Dana Știube Adrian Ciulpan Florina Stoica Simona Ioana Șipoș Cosmin Cîtu Florin Gorun Mărioara Boia |
| author_sort | Daniela Eugenia Popescu |
| collection | DOAJ |
| description | During the last decades, a growing number of studies have shown that infections during pregnancy have an important impact on both pregnant women and their fetuses. Our goal was to include newborns from pregnancies with SARS-CoV-2 infection and to investigate the extension of neonatal complications using cardiac, abdominal, and cerebral ultrasonography; hearing testing; and indirect ophthalmoscopy. Likewise, neonates whose mothers were vaccinated against COVID-19 during pregnancy and those from pathology-free pregnancies were examined. A total of 458 mother–newborn dyads were included over a period of 10 months and divided into three groups: the COVID-19 group, vaccine group, and control group. Although six cardiac malformations were found in the COVID-19 group, no correlation was made compared to the vaccine and control group (<i>p</i> = 0.07). Grade 1 intraventricular hemorrhage and hypoxic ischemic encephalopathy were the most prevalent among neonates from mothers with SARS-CoV-2 infection (<i>p</i> = 0.002 and <i>p</i> < 0.001, respectively). The kidney anomaly found to be most frequent in this group was grade 1 unilateral hydronephrosis (<i>p</i> < 0.001). COVID-19 disease during the gestational period had no effect on the auditory or visual function. Our findings highlight the importance of implementing proper infection control practices for future mothers, and by continuing to investigate this topic, we can gather valuable insights that will improve neonatal health in this context. |
| first_indexed | 2024-03-07T22:24:17Z |
| format | Article |
| id | doaj.art-f87e1e880ccc490a90d98d3c291edf1d |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-07T22:24:17Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f87e1e880ccc490a90d98d3c291edf1d2024-02-23T15:24:41ZengMDPI AGLife2075-17292024-02-0114222410.3390/life14020224How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal PregnancyDaniela Eugenia Popescu0Ana Maria Cristina Jura1Dana Știube2Adrian Ciulpan3Florina Stoica4Simona Ioana Șipoș5Cosmin Cîtu6Florin Gorun7Mărioara Boia8Department of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Neonatology, Premiere Hospital, Regina Maria Health Network, Calea Aradului, No. 113, 300645 Timisoara, RomaniaDepartment of Pediatrics, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, RomaniaDepartment of Ophthalmology, Emergency Municipal Clinical Hospital, Gheorghe Dima Street 5, 300254 Timisoara, RomaniaDepartment of Pharmacology, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDepartment of Obstetrics and Gynecology, “Victor Babeş” University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, RomaniaDuring the last decades, a growing number of studies have shown that infections during pregnancy have an important impact on both pregnant women and their fetuses. Our goal was to include newborns from pregnancies with SARS-CoV-2 infection and to investigate the extension of neonatal complications using cardiac, abdominal, and cerebral ultrasonography; hearing testing; and indirect ophthalmoscopy. Likewise, neonates whose mothers were vaccinated against COVID-19 during pregnancy and those from pathology-free pregnancies were examined. A total of 458 mother–newborn dyads were included over a period of 10 months and divided into three groups: the COVID-19 group, vaccine group, and control group. Although six cardiac malformations were found in the COVID-19 group, no correlation was made compared to the vaccine and control group (<i>p</i> = 0.07). Grade 1 intraventricular hemorrhage and hypoxic ischemic encephalopathy were the most prevalent among neonates from mothers with SARS-CoV-2 infection (<i>p</i> = 0.002 and <i>p</i> < 0.001, respectively). The kidney anomaly found to be most frequent in this group was grade 1 unilateral hydronephrosis (<i>p</i> < 0.001). COVID-19 disease during the gestational period had no effect on the auditory or visual function. Our findings highlight the importance of implementing proper infection control practices for future mothers, and by continuing to investigate this topic, we can gather valuable insights that will improve neonatal health in this context.https://www.mdpi.com/2075-1729/14/2/224pregnancyCOVID-19neonatalultrasoundinfectious diseasesSARS-CoV-2 |
| spellingShingle | Daniela Eugenia Popescu Ana Maria Cristina Jura Dana Știube Adrian Ciulpan Florina Stoica Simona Ioana Șipoș Cosmin Cîtu Florin Gorun Mărioara Boia How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy Life pregnancy COVID-19 neonatal ultrasound infectious diseases SARS-CoV-2 |
| title | How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy |
| title_full | How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy |
| title_fullStr | How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy |
| title_full_unstemmed | How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy |
| title_short | How Much Does SARS-CoV-2 Infection during Pregnancy Affect the Neonatal Brain, Heart, and Kidney? A Parallel between COVID-19, Vaccination, and Normal Pregnancy |
| title_sort | how much does sars cov 2 infection during pregnancy affect the neonatal brain heart and kidney a parallel between covid 19 vaccination and normal pregnancy |
| topic | pregnancy COVID-19 neonatal ultrasound infectious diseases SARS-CoV-2 |
| url | https://www.mdpi.com/2075-1729/14/2/224 |
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