Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickens
ABSTRACT: It has been reported that dietary administration of Bacillus subtilis KC1 is effective in alleviating lung injury induced by Mycoplasma gallisepticum (MG) infection in chickens. However, the underlying molecular mechanism of B. subtilis KC1 against MG infection is still unclear. The purpos...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579123003437 |
| _version_ | 1797770165966864384 |
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| author | Xueping Chen Muhammad Ishfaq Fangyuan Hu Qian Zheng Xiang Hu Jian Wang Nairui Huo |
| author_facet | Xueping Chen Muhammad Ishfaq Fangyuan Hu Qian Zheng Xiang Hu Jian Wang Nairui Huo |
| author_sort | Xueping Chen |
| collection | DOAJ |
| description | ABSTRACT: It has been reported that dietary administration of Bacillus subtilis KC1 is effective in alleviating lung injury induced by Mycoplasma gallisepticum (MG) infection in chickens. However, the underlying molecular mechanism of B. subtilis KC1 against MG infection is still unclear. The purpose of this study was to determine whether B. subtilis KC1 could alleviate MG infection-induced lung injury in chickens by regulating their gut microbiota. The results of this study indicate that B. subtilis KC1 supplementation has the potential to alleviate MG infection-induced lung injury as reflected by reduced MG colonization, reduced pathologic changes, and decreased production of pro-inflammatory cytokines. In addition, B. subtilis KC1 supplementation was partially effective in alleviating the gut microbiota disorder caused by MG infection. Importantly, B. subtilis KC1 enriched the beneficial Bifidobacterium animalis in gut and thus reversed indole metabolic dysfunction caused by MG infection. B. subtilis KC1 supplementation increased levels of indole, which enhanced aryl hydrocarbon receptor activation, improving barrier function and alleviating lung inflammation caused by MG. Overall, this study indicates that B. subtilis KC1 has a “gut-lung axis” mechanism that can reduce the severity of MG infection by enriching intestinal B. animalis and regulating indole metabolism. |
| first_indexed | 2024-03-12T21:18:23Z |
| format | Article |
| id | doaj.art-f87e57aaf65342eca232fb00dc018243 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-03-12T21:18:23Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-f87e57aaf65342eca232fb00dc0182432023-07-29T04:34:27ZengElsevierPoultry Science0032-57912023-08-011028102824Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickensXueping Chen0Muhammad Ishfaq1Fangyuan Hu2Qian Zheng3Xiang Hu4Jian Wang5Nairui Huo6College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, P. R. ChinaCollege of Computer Science, Huanggang Normal University, Huanggang, 438000, P. R. ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, P. R. ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, P. R. ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, P. R. ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, P. R. ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801, P. R. China; Corresponding author:ABSTRACT: It has been reported that dietary administration of Bacillus subtilis KC1 is effective in alleviating lung injury induced by Mycoplasma gallisepticum (MG) infection in chickens. However, the underlying molecular mechanism of B. subtilis KC1 against MG infection is still unclear. The purpose of this study was to determine whether B. subtilis KC1 could alleviate MG infection-induced lung injury in chickens by regulating their gut microbiota. The results of this study indicate that B. subtilis KC1 supplementation has the potential to alleviate MG infection-induced lung injury as reflected by reduced MG colonization, reduced pathologic changes, and decreased production of pro-inflammatory cytokines. In addition, B. subtilis KC1 supplementation was partially effective in alleviating the gut microbiota disorder caused by MG infection. Importantly, B. subtilis KC1 enriched the beneficial Bifidobacterium animalis in gut and thus reversed indole metabolic dysfunction caused by MG infection. B. subtilis KC1 supplementation increased levels of indole, which enhanced aryl hydrocarbon receptor activation, improving barrier function and alleviating lung inflammation caused by MG. Overall, this study indicates that B. subtilis KC1 has a “gut-lung axis” mechanism that can reduce the severity of MG infection by enriching intestinal B. animalis and regulating indole metabolism.http://www.sciencedirect.com/science/article/pii/S0032579123003437Bacillus subtilisMycoplasma gallisepticumBifidobacterium animalisindolelung injury |
| spellingShingle | Xueping Chen Muhammad Ishfaq Fangyuan Hu Qian Zheng Xiang Hu Jian Wang Nairui Huo Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickens Poultry Science Bacillus subtilis Mycoplasma gallisepticum Bifidobacterium animalis indole lung injury |
| title | Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickens |
| title_full | Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickens |
| title_fullStr | Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickens |
| title_full_unstemmed | Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickens |
| title_short | Bacillus subtilis KC1 prevents Mycoplasma gallisepticum-induced lung injury by enhancing intestinal Bifidobacterium animalis and regulating indole metabolism in chickens |
| title_sort | bacillus subtilis kc1 prevents mycoplasma gallisepticum induced lung injury by enhancing intestinal bifidobacterium animalis and regulating indole metabolism in chickens |
| topic | Bacillus subtilis Mycoplasma gallisepticum Bifidobacterium animalis indole lung injury |
| url | http://www.sciencedirect.com/science/article/pii/S0032579123003437 |
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