Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study
Cancer patients having moderate to severe pain need immediate pain relief. Immediate release formulation of morphine is not available in Bangladesh. This open label randomised two phase crossover clinical trial was conducted to compare strength, efficacy, and tolerability of oral morphine solution p...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2015-02-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/21754 |
| _version_ | 1819180000586235904 |
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| author | Rawshan Ara Perveen Md. Sayedur Rahman |
| author_facet | Rawshan Ara Perveen Md. Sayedur Rahman |
| author_sort | Rawshan Ara Perveen |
| collection | DOAJ |
| description | Cancer patients having moderate to severe pain need immediate pain relief. Immediate release formulation of morphine is not available in Bangladesh. This open label randomised two phase crossover clinical trial was conducted to compare strength, efficacy, and tolerability of oral morphine solution prepared from morphine sulfate injectable formulation and sustained release tablet with and without added preservatives. Concentration of morphine in solutions both with and without added preservative was highest on the first day and then gradually decreased. No difference between two storage temperatures on first day, but highly significant difference afterwards. Rate of degradation of morphine in solution with added preservative was significantly slower. The present study revealed that the solutions prepared from sustained release tablets and injectable formulation with added preservative could be an option to control severe pain in cancer patients. To introduce the present research finding in clinical practice, this has to be accepted institutionally. |
| first_indexed | 2024-12-22T22:07:23Z |
| format | Article |
| id | doaj.art-f881a7d9618e4641a63e06eb96c5f8f1 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-22T22:07:23Z |
| publishDate | 2015-02-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-f881a7d9618e4641a63e06eb96c5f8f12022-12-21T18:10:57ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-02-0110110.3329/bjp.v10i1.21754Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative studyRawshan Ara Perveen0Md. Sayedur Rahman1Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, DhakaDepartment of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, DhakaCancer patients having moderate to severe pain need immediate pain relief. Immediate release formulation of morphine is not available in Bangladesh. This open label randomised two phase crossover clinical trial was conducted to compare strength, efficacy, and tolerability of oral morphine solution prepared from morphine sulfate injectable formulation and sustained release tablet with and without added preservatives. Concentration of morphine in solutions both with and without added preservative was highest on the first day and then gradually decreased. No difference between two storage temperatures on first day, but highly significant difference afterwards. Rate of degradation of morphine in solution with added preservative was significantly slower. The present study revealed that the solutions prepared from sustained release tablets and injectable formulation with added preservative could be an option to control severe pain in cancer patients. To introduce the present research finding in clinical practice, this has to be accepted institutionally.https://www.banglajol.info/index.php/BJP/article/view/21754MorphinePalliative Care |
| spellingShingle | Rawshan Ara Perveen Md. Sayedur Rahman Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study Bangladesh Journal of Pharmacology Morphine Palliative Care |
| title | Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study |
| title_full | Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study |
| title_fullStr | Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study |
| title_full_unstemmed | Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study |
| title_short | Strength, efficacy and tolerability of morphine solution with and without added preservatives: A comparative study |
| title_sort | strength efficacy and tolerability of morphine solution with and without added preservatives a comparative study |
| topic | Morphine Palliative Care |
| url | https://www.banglajol.info/index.php/BJP/article/view/21754 |
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