Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris
Abstract Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Journal of Intensive Care |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40560-018-0342-4 |
| _version_ | 1818596583815512064 |
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| author | Andrea Cortegiani Giovanni Misseri Teresa Fasciana Anna Giammanco Antonino Giarratano Anuradha Chowdhary |
| author_facet | Andrea Cortegiani Giovanni Misseri Teresa Fasciana Anna Giammanco Antonino Giarratano Anuradha Chowdhary |
| author_sort | Andrea Cortegiani |
| collection | DOAJ |
| description | Abstract Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of C. auris are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. The aim of this review was to provide an updated and comprehensive report of the global spread of C. auris, focusing on clinical and microbiological characteristics, mechanisms of virulence and antifungal resistance, and efficacy of available control, preventive, and therapeutic strategies. |
| first_indexed | 2024-12-16T11:34:13Z |
| format | Article |
| id | doaj.art-f883a559753a4d4296771c8c74f35b03 |
| institution | Directory Open Access Journal |
| issn | 2052-0492 |
| language | English |
| last_indexed | 2024-12-16T11:34:13Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Intensive Care |
| spelling | doaj.art-f883a559753a4d4296771c8c74f35b032022-12-21T22:33:10ZengBMCJournal of Intensive Care2052-04922018-10-016111310.1186/s40560-018-0342-4Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida aurisAndrea Cortegiani0Giovanni Misseri1Teresa Fasciana2Anna Giammanco3Antonino Giarratano4Anuradha Chowdhary5Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.). Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone. University of Palermo, Italy, University of PalermoDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.). Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone. University of Palermo, Italy, University of PalermoDepartment of Sciences for Health Promotion and Mother and Child Care, University of PalermoDepartment of Sciences for Health Promotion and Mother and Child Care, University of PalermoDepartment of Surgical, Oncological and Oral Science (Di.Chir.On.S.). Section of Anesthesia, Analgesia, Intensive Care and Emergency. Policlinico Paolo Giaccone. University of Palermo, Italy, University of PalermoDepartment of Medical Mycology, Vallabhbhai Patel Chest Institute, University of DelhiAbstract Candida spp. infections are a major cause of morbidity and mortality in critically ill patients. Candida auris is an emerging multi-drug-resistant fungus that is rapidly spreading worldwide. Since the first reports in 2009, many isolates across five continents have been identified as agents of hospital-associated infections. Independent and simultaneous outbreaks of C. auris are becoming a major concern for healthcare and scientific community. Moreover, laboratory misidentification and multi-drug-resistant profiles, rarely observed for other non-albicans Candida species, result in difficult eradication and frequent therapeutic failures of C. auris infections. The aim of this review was to provide an updated and comprehensive report of the global spread of C. auris, focusing on clinical and microbiological characteristics, mechanisms of virulence and antifungal resistance, and efficacy of available control, preventive, and therapeutic strategies.http://link.springer.com/article/10.1186/s40560-018-0342-4C. aurisCandidaCandidemiaInvasive fungal infectionAntimicrobial resistanceAntifungal resistance |
| spellingShingle | Andrea Cortegiani Giovanni Misseri Teresa Fasciana Anna Giammanco Antonino Giarratano Anuradha Chowdhary Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris Journal of Intensive Care C. auris Candida Candidemia Invasive fungal infection Antimicrobial resistance Antifungal resistance |
| title | Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris |
| title_full | Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris |
| title_fullStr | Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris |
| title_full_unstemmed | Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris |
| title_short | Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris |
| title_sort | epidemiology clinical characteristics resistance and treatment of infections by candida auris |
| topic | C. auris Candida Candidemia Invasive fungal infection Antimicrobial resistance Antifungal resistance |
| url | http://link.springer.com/article/10.1186/s40560-018-0342-4 |
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