Design, synthesis and antiproliferative evaluation of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors

Design, synthesis and antiproliferative evaluation of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivatives as tubulin polymerization inhibitors

Malignant transformations are dependent on an aberrant increase in tubulin and microtubule activities for cancer cell growth, migration, invasion and metastasis. The present work includes design and synthesis of a new series of lipidated 1,3-diaryl propenones and their cyclized pyrimidine derivative...

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Bibliographic Details
Main Authors: Fatma Elzahraa Ali, Ola I.A. Salem, Mohamed A. El-Mokhtar, Ahmed S. Aboraia, Samia G. Abdel-Moty, Abu-Baker M. Abdel-Aal
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Results in Chemistry
Subjects:
Cancer
Tubulin
Chalcone
Pyrimidine
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715623002552

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