Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis
<h4>Background</h4> Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investiga...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568107/?tool=EBI |
| _version_ | 1828950444986073088 |
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| author | Chih-Chien Wang Chih-Yun Huang Meng-Chang Lee Dung-Jang Tsai Chia-Chun Wu Sui-Lung Su |
| author_facet | Chih-Chien Wang Chih-Yun Huang Meng-Chang Lee Dung-Jang Tsai Chia-Chun Wu Sui-Lung Su |
| author_sort | Chih-Chien Wang |
| collection | DOAJ |
| description | <h4>Background</h4> Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained. <h4>Objective</h4> This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA. <h4>Methods</h4> Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren–Lawrence grading system was used to identify the knee OA cases. A meta-analysis was conducted including related studies published until 2020 from PubMed, Embase, and previous meta-analysis to improve the evidence level of the current study. The results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate the effect of this polymorphism on knee OA risk. The TSA was used to estimate the sample sizes required in this issue. <h4>Results</h4> A nonsignificant association was found between the AA genotype and knee OA [adjusted OR, 0.84; 95% CI, 0.62–1.15) in the recessive model] in the present case–control study, and analysis of other genetic models showed a similar trend. After adding the critical case–control samples for Asians, the TNF-α G-308A, AA genotype exhibited 2.57 times more risk of developing arthritis when compared with the GG + GA genotype (95% CI, 1.56–4.23), and the cumulative samples for TSA (n = 2182) were sufficient to obtain a definite conclusion. <h4>Conclusions</h4> The results of this meta-analysis revealed that the TNF-α G-308A, AA genotype is a susceptible genotype for OA in the Asian population. This study integrated all current evidence to arrive at this conclusion, suggesting that future studies on Asians are not required. |
| first_indexed | 2024-12-14T06:23:11Z |
| format | Article |
| id | doaj.art-f886bbfa1ef249f9bbb44e52021d75dc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T06:23:11Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f886bbfa1ef249f9bbb44e52021d75dc2022-12-21T23:13:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-011611Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysisChih-Chien WangChih-Yun HuangMeng-Chang LeeDung-Jang TsaiChia-Chun WuSui-Lung Su<h4>Background</h4> Osteoarthritis (OA) is an important health issue in elderly people. Many studies have suggested that genetic factors are important risk factors for OA, of which tumor necrosis factor-α (TNF-α) is one of the most examined genes. Moreover, several studies have investigated the relationship between TNF-α G-308A polymorphisms and OA risk, but consistent results have not been obtained. <h4>Objective</h4> This study examines the association between TNF-α G-308A polymorphisms and knee OA. Moreover, meta-analysis and trial sequential analysis (TSA) was used to determine whether this is a susceptibility gene for knee OA. <h4>Methods</h4> Between 2015 and 2019, 591 knee OA cases and 536 healthy controls were recruited. The Kellgren–Lawrence grading system was used to identify the knee OA cases. A meta-analysis was conducted including related studies published until 2020 from PubMed, Embase, and previous meta-analysis to improve the evidence level of the current study. The results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) to evaluate the effect of this polymorphism on knee OA risk. The TSA was used to estimate the sample sizes required in this issue. <h4>Results</h4> A nonsignificant association was found between the AA genotype and knee OA [adjusted OR, 0.84; 95% CI, 0.62–1.15) in the recessive model] in the present case–control study, and analysis of other genetic models showed a similar trend. After adding the critical case–control samples for Asians, the TNF-α G-308A, AA genotype exhibited 2.57 times more risk of developing arthritis when compared with the GG + GA genotype (95% CI, 1.56–4.23), and the cumulative samples for TSA (n = 2182) were sufficient to obtain a definite conclusion. <h4>Conclusions</h4> The results of this meta-analysis revealed that the TNF-α G-308A, AA genotype is a susceptible genotype for OA in the Asian population. This study integrated all current evidence to arrive at this conclusion, suggesting that future studies on Asians are not required.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568107/?tool=EBI |
| spellingShingle | Chih-Chien Wang Chih-Yun Huang Meng-Chang Lee Dung-Jang Tsai Chia-Chun Wu Sui-Lung Su Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis PLoS ONE |
| title | Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis |
| title_full | Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis |
| title_fullStr | Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis |
| title_full_unstemmed | Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis |
| title_short | Genetic association between TNF-α G-308A and osteoarthritis in Asians: A case–control study and meta-analysis |
| title_sort | genetic association between tnf α g 308a and osteoarthritis in asians a case control study and meta analysis |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568107/?tool=EBI |
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