Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis
The child microbiome, including gut and skin communities, is shaped by a multitude of factors, and breastfeeding is one of the most essential. Food allergy (FA) and atopic dermatitis (AD) are among the most common diseases in pediatrics, with the prevalence of each up to 6% and 20%, respectively. Th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3600 |
| _version_ | 1797513590401400832 |
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| author | Marcin Gołębiewski Ewa Łoś-Rycharska Marcin Sikora Tomasz Grzybowski Marta Gorzkiewicz Aneta Krogulska |
| author_facet | Marcin Gołębiewski Ewa Łoś-Rycharska Marcin Sikora Tomasz Grzybowski Marta Gorzkiewicz Aneta Krogulska |
| author_sort | Marcin Gołębiewski |
| collection | DOAJ |
| description | The child microbiome, including gut and skin communities, is shaped by a multitude of factors, and breastfeeding is one of the most essential. Food allergy (FA) and atopic dermatitis (AD) are among the most common diseases in pediatrics, with the prevalence of each up to 6% and 20%, respectively. Therefore, we aimed at finding differences between the fecal and skin microbiomes of FA and AD patients in the context of breastfeeding, by means of the Illumina sequencing of 16S rRNA gene fragment libraries amplified from the total DNA isolated from samples collected from allergic and healthy infants. We also analyzed milk samples from the mothers of the examined children and searched for patterns of incidence suggesting milk influence on an infant’s allergy status. Here we show that a mother’s milk influences her child’s fecal and skin microbiomes and identify <i>Acinetobacter</i> as the taxon whose abundance is correlated with milk and child-derived samples. We demonstrate that breastfeeding makes allergic children's fecal and skin communities more similar to those of healthy infants than in the case of formula-feeding. We also identify signature taxa that might be important in maintaining health or allergy development. |
| first_indexed | 2024-03-10T06:18:43Z |
| format | Article |
| id | doaj.art-f8871dd59ae9405fbcbbb67441532548 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:18:43Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f8871dd59ae9405fbcbbb674415325482023-11-22T19:31:11ZengMDPI AGNutrients2072-66432021-10-011310360010.3390/nu13103600Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot AnalysisMarcin Gołębiewski0Ewa Łoś-Rycharska1Marcin Sikora2Tomasz Grzybowski3Marta Gorzkiewicz4Aneta Krogulska5Department of Plant Physiology and Biotechnology, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Pediatrics, Allergology and Gastroenterology, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, PolandInterdisciplinary Centre of Modern Technologies, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Forensic Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Forensic Medicine, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, PolandDepartment of Pediatrics, Allergology and Gastroenterology, Collegium Medicum Bydgoszcz, Nicolaus Copernicus University, 87-100 Torun, PolandThe child microbiome, including gut and skin communities, is shaped by a multitude of factors, and breastfeeding is one of the most essential. Food allergy (FA) and atopic dermatitis (AD) are among the most common diseases in pediatrics, with the prevalence of each up to 6% and 20%, respectively. Therefore, we aimed at finding differences between the fecal and skin microbiomes of FA and AD patients in the context of breastfeeding, by means of the Illumina sequencing of 16S rRNA gene fragment libraries amplified from the total DNA isolated from samples collected from allergic and healthy infants. We also analyzed milk samples from the mothers of the examined children and searched for patterns of incidence suggesting milk influence on an infant’s allergy status. Here we show that a mother’s milk influences her child’s fecal and skin microbiomes and identify <i>Acinetobacter</i> as the taxon whose abundance is correlated with milk and child-derived samples. We demonstrate that breastfeeding makes allergic children's fecal and skin communities more similar to those of healthy infants than in the case of formula-feeding. We also identify signature taxa that might be important in maintaining health or allergy development.https://www.mdpi.com/2072-6643/13/10/3600atopic dermatitisdysbacteriosis/microbial imbalancefood allergyfecesmother’s milkmicrobiota |
| spellingShingle | Marcin Gołębiewski Ewa Łoś-Rycharska Marcin Sikora Tomasz Grzybowski Marta Gorzkiewicz Aneta Krogulska Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis Nutrients atopic dermatitis dysbacteriosis/microbial imbalance food allergy feces mother’s milk microbiota |
| title | Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis |
| title_full | Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis |
| title_fullStr | Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis |
| title_full_unstemmed | Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis |
| title_short | Mother’s Milk Microbiome Shaping Fecal and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Analysis |
| title_sort | mother s milk microbiome shaping fecal and skin microbiota in infants with food allergy and atopic dermatitis a pilot analysis |
| topic | atopic dermatitis dysbacteriosis/microbial imbalance food allergy feces mother’s milk microbiota |
| url | https://www.mdpi.com/2072-6643/13/10/3600 |
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