The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-Analysis

The purpose of the current study is to describe the prevalence of <i>Pseudomonas aeruginosa</i> (PA)-producing MβL among Brazilian isolates and the frequency of <i>bla</i><sub>SPM-1</sub> in MβL-PA-producing isolates. From January 2009 to August 2023, we carried o...

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Main Authors: Pabllo Antonny Silva Dos Santos, Marcos Jessé Abrahão Silva, Maria Isabel Montoril Gouveia, Luana Nepomuceno Gondim Costa Lima, Ana Judith Pires Garcia Quaresma, Patrícia Danielle Lima De Lima, Danielle Murici Brasiliense, Karla Valéria Batista Lima, Yan Corrêa Rodrigues
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Microorganisms
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Online Access:https://www.mdpi.com/2076-2607/11/9/2366
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author Pabllo Antonny Silva Dos Santos
Marcos Jessé Abrahão Silva
Maria Isabel Montoril Gouveia
Luana Nepomuceno Gondim Costa Lima
Ana Judith Pires Garcia Quaresma
Patrícia Danielle Lima De Lima
Danielle Murici Brasiliense
Karla Valéria Batista Lima
Yan Corrêa Rodrigues
author_facet Pabllo Antonny Silva Dos Santos
Marcos Jessé Abrahão Silva
Maria Isabel Montoril Gouveia
Luana Nepomuceno Gondim Costa Lima
Ana Judith Pires Garcia Quaresma
Patrícia Danielle Lima De Lima
Danielle Murici Brasiliense
Karla Valéria Batista Lima
Yan Corrêa Rodrigues
author_sort Pabllo Antonny Silva Dos Santos
collection DOAJ
description The purpose of the current study is to describe the prevalence of <i>Pseudomonas aeruginosa</i> (PA)-producing MβL among Brazilian isolates and the frequency of <i>bla</i><sub>SPM-1</sub> in MβL-PA-producing isolates. From January 2009 to August 2023, we carried out an investigation on this subject in the internet databases SciELO, PubMed, Science Direct, and LILACS. A total of 20 papers that met the eligibility requirements were chosen by comprehensive meta-analysis software v2.2 for data retrieval and analysis by one meta-analysis using a fixed-effects model for the two investigations. The prevalence of MβL-producing <i>P. aeruginosa</i> was 35.8% or 0.358 (95% CI = 0.324–0.393). The studies’ differences were significantly different from one another (x<sup>2</sup> = 243.15; <i>p</i> < 0.001; I<sup>2</sup> = 92.18%), so they were divided into subgroups based on Brazilian regions. There was indication of asymmetry in the meta-analyses’ publishing bias funnel plot; so, a meta-regression was conducted by the study’s publication year. According to the findings of Begg’s test, no discernible publishing bias was found. <i>bla</i><sub>SPM-1</sub> prevalence was estimated at 66.9% or 0.669 in MβL-PA isolates (95% CI = 0.593–0.738). The analysis of this one showed an average heterogeneity (x<sup>2</sup> = 90.93; <i>p</i> < 0.001; I<sup>2</sup> = 80.20%). According to the results of Begg’s test and a funnel plot, no discernible publishing bias was found. The research showed that MβL-<i>P. aeruginosa</i> and SPM-1 isolates were relatively common among individuals in Brazil. <i>P. aeruginosa</i> and other opportunistic bacteria are spreading quickly and causing severe infections, so efforts are needed to pinpoint risk factors, reservoirs, transmission pathways, and the origin of infection.
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spelling doaj.art-f88756a1d49e42aebdafd15a13aaafb32023-11-19T12:04:22ZengMDPI AGMicroorganisms2076-26072023-09-01119236610.3390/microorganisms11092366The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-AnalysisPabllo Antonny Silva Dos Santos0Marcos Jessé Abrahão Silva1Maria Isabel Montoril Gouveia2Luana Nepomuceno Gondim Costa Lima3Ana Judith Pires Garcia Quaresma4Patrícia Danielle Lima De Lima5Danielle Murici Brasiliense6Karla Valéria Batista Lima7Yan Corrêa Rodrigues8Program in Parasitic Biology in the Amazon Region (PPGBPA), State University of Pará (UEPA), Belém 66087-662, PA, BrazilBacteriology and Mycology Section, Evandro Chagas Institute (SABMI/IEC), Ministry of Health, Ananindeua 67030-000, PA, BrazilBacteriology and Mycology Section, Evandro Chagas Institute (SABMI/IEC), Ministry of Health, Ananindeua 67030-000, PA, BrazilProgram in Parasitic Biology in the Amazon Region (PPGBPA), State University of Pará (UEPA), Belém 66087-662, PA, BrazilBacteriology and Mycology Section, Evandro Chagas Institute (SABMI/IEC), Ministry of Health, Ananindeua 67030-000, PA, BrazilProgram in Parasitic Biology in the Amazon Region (PPGBPA), State University of Pará (UEPA), Belém 66087-662, PA, BrazilProgram in Parasitic Biology in the Amazon Region (PPGBPA), State University of Pará (UEPA), Belém 66087-662, PA, BrazilProgram in Parasitic Biology in the Amazon Region (PPGBPA), State University of Pará (UEPA), Belém 66087-662, PA, BrazilBacteriology and Mycology Section, Evandro Chagas Institute (SABMI/IEC), Ministry of Health, Ananindeua 67030-000, PA, BrazilThe purpose of the current study is to describe the prevalence of <i>Pseudomonas aeruginosa</i> (PA)-producing MβL among Brazilian isolates and the frequency of <i>bla</i><sub>SPM-1</sub> in MβL-PA-producing isolates. From January 2009 to August 2023, we carried out an investigation on this subject in the internet databases SciELO, PubMed, Science Direct, and LILACS. A total of 20 papers that met the eligibility requirements were chosen by comprehensive meta-analysis software v2.2 for data retrieval and analysis by one meta-analysis using a fixed-effects model for the two investigations. The prevalence of MβL-producing <i>P. aeruginosa</i> was 35.8% or 0.358 (95% CI = 0.324–0.393). The studies’ differences were significantly different from one another (x<sup>2</sup> = 243.15; <i>p</i> < 0.001; I<sup>2</sup> = 92.18%), so they were divided into subgroups based on Brazilian regions. There was indication of asymmetry in the meta-analyses’ publishing bias funnel plot; so, a meta-regression was conducted by the study’s publication year. According to the findings of Begg’s test, no discernible publishing bias was found. <i>bla</i><sub>SPM-1</sub> prevalence was estimated at 66.9% or 0.669 in MβL-PA isolates (95% CI = 0.593–0.738). The analysis of this one showed an average heterogeneity (x<sup>2</sup> = 90.93; <i>p</i> < 0.001; I<sup>2</sup> = 80.20%). According to the results of Begg’s test and a funnel plot, no discernible publishing bias was found. The research showed that MβL-<i>P. aeruginosa</i> and SPM-1 isolates were relatively common among individuals in Brazil. <i>P. aeruginosa</i> and other opportunistic bacteria are spreading quickly and causing severe infections, so efforts are needed to pinpoint risk factors, reservoirs, transmission pathways, and the origin of infection.https://www.mdpi.com/2076-2607/11/9/2366<i>Pseudomonas aeruginosa</i>meta-analysisBrazilMΒL<i>bla</i><sub>SPM-1</sub>
spellingShingle Pabllo Antonny Silva Dos Santos
Marcos Jessé Abrahão Silva
Maria Isabel Montoril Gouveia
Luana Nepomuceno Gondim Costa Lima
Ana Judith Pires Garcia Quaresma
Patrícia Danielle Lima De Lima
Danielle Murici Brasiliense
Karla Valéria Batista Lima
Yan Corrêa Rodrigues
The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-Analysis
Microorganisms
<i>Pseudomonas aeruginosa</i>
meta-analysis
Brazil
MΒL
<i>bla</i><sub>SPM-1</sub>
title The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-Analysis
title_full The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-Analysis
title_fullStr The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-Analysis
title_full_unstemmed The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-Analysis
title_short The Prevalence of Metallo-Beta-Lactamese-(MβL)-Producing <i>Pseudomonas aeruginosa</i> Isolates in Brazil: A Systematic Review and Meta-Analysis
title_sort prevalence of metallo beta lactamese mβl producing i pseudomonas aeruginosa i isolates in brazil a systematic review and meta analysis
topic <i>Pseudomonas aeruginosa</i>
meta-analysis
Brazil
MΒL
<i>bla</i><sub>SPM-1</sub>
url https://www.mdpi.com/2076-2607/11/9/2366
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