Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme
This prospective study was aimed to test changes in hemostasis in patients with GBM, occurring at baseline (before surgery, time 0, T0) and 2 (T2), 24 (T24), and 48-hour (T48) after surgery. We enrolled consecutive patients subjected to GBM resection (GBR group; N = 60), laparoscopic colon cancer re...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Platelets |
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| Online Access: | http://dx.doi.org/10.1080/09537104.2023.2216802 |
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| author | Santiago R. Leal-Noval Manuel Casado Cancela Palomares José L. Narros José L. García-Garmendia Ginés Escolar Diego X. Cuenca Klaus Görlinger |
| author_facet | Santiago R. Leal-Noval Manuel Casado Cancela Palomares José L. Narros José L. García-Garmendia Ginés Escolar Diego X. Cuenca Klaus Görlinger |
| author_sort | Santiago R. Leal-Noval |
| collection | DOAJ |
| description | This prospective study was aimed to test changes in hemostasis in patients with GBM, occurring at baseline (before surgery, time 0, T0) and 2 (T2), 24 (T24), and 48-hour (T48) after surgery. We enrolled consecutive patients subjected to GBM resection (GBR group; N = 60), laparoscopic colon cancer resection (comparative CCR group; N = 40), and healthy blood donors (HBD group; N = 40). We performed 1. conventional coagulation tests 2. ROTEM (rotational thromboelastometry) parameters and 3. platelet function tests, including PFA-200 closure time when stimulated by collagen/epinephrine (COL-EPI) and ROTEM platelet, using three different activators (arachnoid acid in ARATEM, adenosine diphosphate in ADPTEM, and thrombin receptor-activating peptide-6 in TRAPTEM). Variables associated with unfavorable 1-year clinical outcome were investigated, too. We observed in GBR patients that platelet aggregometry, as assessed by ROTEM platelet parameters, was significantly impaired along with a shortened closure time. These changes were evident from T0 to T48. A decreased area under the aggregation curve in TRAPTEM was associated with improved survival (adjusted odd ratio (95% CI), 1.03 (1.01–1.06)). This study suggests that patients with GBM presented a decreased platelet aggregation from before surgery and thorough the postoperative period. Decreased platelet aggregation improved clinical outcome. |
| first_indexed | 2024-03-12T00:25:44Z |
| format | Article |
| id | doaj.art-f8887d63eff748d99003714446a507e7 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:44Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-f8887d63eff748d99003714446a507e72023-09-15T10:38:12ZengTaylor & Francis GroupPlatelets0953-71041369-16352023-12-0134110.1080/09537104.2023.22168022216802Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiformeSantiago R. Leal-Noval0Manuel Casado1Cancela Palomares2José L. Narros3José L. García-Garmendia4Ginés Escolar5Diego X. Cuenca6Klaus Görlinger7University Hospital ‘Virgen del Rocío’University Hospital ‘Virgen del Rocío’University Hospital ‘Virgen del Rocío’University Hospital ‘Virgen del Rocío’Master on Design and Statistics for Health Sciences, Hospital ‘San Juan de Dios del Aljarafe’University Hospital ClinicUniversity Hospital ‘Virgen del Rocío’University Hospital EssenThis prospective study was aimed to test changes in hemostasis in patients with GBM, occurring at baseline (before surgery, time 0, T0) and 2 (T2), 24 (T24), and 48-hour (T48) after surgery. We enrolled consecutive patients subjected to GBM resection (GBR group; N = 60), laparoscopic colon cancer resection (comparative CCR group; N = 40), and healthy blood donors (HBD group; N = 40). We performed 1. conventional coagulation tests 2. ROTEM (rotational thromboelastometry) parameters and 3. platelet function tests, including PFA-200 closure time when stimulated by collagen/epinephrine (COL-EPI) and ROTEM platelet, using three different activators (arachnoid acid in ARATEM, adenosine diphosphate in ADPTEM, and thrombin receptor-activating peptide-6 in TRAPTEM). Variables associated with unfavorable 1-year clinical outcome were investigated, too. We observed in GBR patients that platelet aggregometry, as assessed by ROTEM platelet parameters, was significantly impaired along with a shortened closure time. These changes were evident from T0 to T48. A decreased area under the aggregation curve in TRAPTEM was associated with improved survival (adjusted odd ratio (95% CI), 1.03 (1.01–1.06)). This study suggests that patients with GBM presented a decreased platelet aggregation from before surgery and thorough the postoperative period. Decreased platelet aggregation improved clinical outcome.http://dx.doi.org/10.1080/09537104.2023.2216802aggregometry, coagulation, glioblastoma, hemostasis, platelet, rotem |
| spellingShingle | Santiago R. Leal-Noval Manuel Casado Cancela Palomares José L. Narros José L. García-Garmendia Ginés Escolar Diego X. Cuenca Klaus Görlinger Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme Platelets aggregometry, coagulation, glioblastoma, hemostasis, platelet, rotem |
| title | Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme |
| title_full | Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme |
| title_fullStr | Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme |
| title_full_unstemmed | Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme |
| title_short | Prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme |
| title_sort | prospective assessment of platelet function in patients undergoing elective resection of glioblastoma multiforme |
| topic | aggregometry, coagulation, glioblastoma, hemostasis, platelet, rotem |
| url | http://dx.doi.org/10.1080/09537104.2023.2216802 |
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