Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis
The ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae – a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex ba...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.877995/full |
| _version_ | 1811305676000985088 |
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| author | Maria Eduarda Souza Guerra Giulia Destro Brenda Vieira Alice S. Lima Lucio Fabio Caldas Ferraz Anders P. Hakansson Michelle Darrieux Thiago Rojas Converso |
| author_facet | Maria Eduarda Souza Guerra Giulia Destro Brenda Vieira Alice S. Lima Lucio Fabio Caldas Ferraz Anders P. Hakansson Michelle Darrieux Thiago Rojas Converso |
| author_sort | Maria Eduarda Souza Guerra |
| collection | DOAJ |
| description | The ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae – a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. We also explore different model systems designed to study biofilm formation in this species. A great number of factors contribute to biofilm establishment and maintenance in K. pneumoniae, which highlights the importance of this mechanism for the bacterial fitness. Some of these molecules could be used in future vaccines against this bacterium. However, there is still a lack of in vivo models to evaluate the contribution of biofilm development to disease pathogenesis. With that in mind, the combination of different methodologies has great potential to provide a more detailed scenario that more accurately reflects the steps and progression of natural infection. |
| first_indexed | 2024-04-13T08:29:37Z |
| format | Article |
| id | doaj.art-f8893691cec5455eaf618bdacef427f3 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T08:29:37Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f8893691cec5455eaf618bdacef427f32022-12-22T02:54:18ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-05-011210.3389/fcimb.2022.877995877995Klebsiella pneumoniae Biofilms and Their Role in Disease PathogenesisMaria Eduarda Souza Guerra0Giulia Destro1Brenda Vieira2Alice S. Lima3Lucio Fabio Caldas Ferraz4Anders P. Hakansson5Michelle Darrieux6Thiago Rojas Converso7Laboratório de Biologia Molecular de Microrganismos, Universidade São Francisco, Bragança Paulista, BrazilLaboratório de Biologia Molecular de Microrganismos, Universidade São Francisco, Bragança Paulista, BrazilLaboratório de Biologia Molecular de Microrganismos, Universidade São Francisco, Bragança Paulista, BrazilLaboratório de Biologia Molecular de Microrganismos, Universidade São Francisco, Bragança Paulista, BrazilLaboratório de Biologia Molecular de Microrganismos, Universidade São Francisco, Bragança Paulista, BrazilDivision of Experimental Infection Medicine, Department of Translational Medicine, Lund University, Malmo, SwedenLaboratório de Biologia Molecular de Microrganismos, Universidade São Francisco, Bragança Paulista, BrazilLaboratório de Biologia Molecular de Microrganismos, Universidade São Francisco, Bragança Paulista, BrazilThe ability to form biofilms is a crucial virulence trait for several microorganisms, including Klebsiella pneumoniae – a Gram-negative encapsulated bacterium often associated with nosocomial infections. It is estimated that 65-80% of bacterial infections are biofilm related. Biofilms are complex bacterial communities composed of one or more species encased in an extracellular matrix made of proteins, carbohydrates and genetic material derived from the bacteria themselves as well as from the host. Bacteria in the biofilm are shielded from immune responses and antibiotics. The present review discusses the characteristics of K. pneumoniae biofilms, factors affecting biofilm development, and their contribution to infections. We also explore different model systems designed to study biofilm formation in this species. A great number of factors contribute to biofilm establishment and maintenance in K. pneumoniae, which highlights the importance of this mechanism for the bacterial fitness. Some of these molecules could be used in future vaccines against this bacterium. However, there is still a lack of in vivo models to evaluate the contribution of biofilm development to disease pathogenesis. With that in mind, the combination of different methodologies has great potential to provide a more detailed scenario that more accurately reflects the steps and progression of natural infection.https://www.frontiersin.org/articles/10.3389/fcimb.2022.877995/fullbiofilmKlebsiella pneumoniaequorum sensingpathogenesisvirulence factors |
| spellingShingle | Maria Eduarda Souza Guerra Giulia Destro Brenda Vieira Alice S. Lima Lucio Fabio Caldas Ferraz Anders P. Hakansson Michelle Darrieux Thiago Rojas Converso Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis Frontiers in Cellular and Infection Microbiology biofilm Klebsiella pneumoniae quorum sensing pathogenesis virulence factors |
| title | Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis |
| title_full | Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis |
| title_fullStr | Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis |
| title_full_unstemmed | Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis |
| title_short | Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis |
| title_sort | klebsiella pneumoniae biofilms and their role in disease pathogenesis |
| topic | biofilm Klebsiella pneumoniae quorum sensing pathogenesis virulence factors |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.877995/full |
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