ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITIS
Liver fibrosis is a reversible response to a wound healing with marked accumulation of extracellular matrix which caused by injury to the liver. Liver fibrosis can be caused by various factors including alcohol and non-alcohol steatohepatitis. The process of fibrosis serves to localize the inflammat...
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| Format: | Article |
| Language: | Indonesian |
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Universitas Sriwijaya
2019-10-01
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| Series: | Jurnal Kedokteran dan Kesehatan |
| Online Access: | https://ejournal.unsri.ac.id/index.php/jkk/article/view/7744 |
| _version_ | 1811225530155925504 |
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| author | Novriantika Lestari |
| author_facet | Novriantika Lestari |
| author_sort | Novriantika Lestari |
| collection | DOAJ |
| description | Liver fibrosis is a reversible response to a wound healing with marked accumulation of extracellular matrix which caused by injury to the liver. Liver fibrosis can be caused by various factors including alcohol and non-alcohol steatohepatitis. The process of fibrosis serves to localize the inflammation during chronic exposure. The hepatic stem cell (HSC) has a key role in the pathogenesis of liver fibrosis. The HSC activation is characterized by increased profibrogenic mediators including members of the TGF-? superfamily. In order to enable signal transduction, the mediator needs to bind to its receptors. The serine/ threonine kinase receptor is a receptor that binds to the TGF-? superfamily ligand, including TGF-?, BMP, activin and other mediators. The ligand receptor-binding activity will stimulate signal transduction that will translocate into the nucleus and phosphorylate various transcription factors that play a role in cell proliferation, differentiation, or apoptosis. There is currently no standard therapy for liver fibrosis. Based on the central role of the serine/ threonine kinase receptor in the pathogenesis of liver fibrosis, it is thought that the use of serine/ threonine kinase inhibitors is a promising therapy. |
| first_indexed | 2024-04-12T09:08:48Z |
| format | Article |
| id | doaj.art-f88c41b9a64f4ea19a82292b96e6b8ca |
| institution | Directory Open Access Journal |
| issn | 2406-7431 2614-0411 |
| language | Indonesian |
| last_indexed | 2024-04-12T09:08:48Z |
| publishDate | 2019-10-01 |
| publisher | Universitas Sriwijaya |
| record_format | Article |
| series | Jurnal Kedokteran dan Kesehatan |
| spelling | doaj.art-f88c41b9a64f4ea19a82292b96e6b8ca2022-12-22T03:39:01ZindUniversitas SriwijayaJurnal Kedokteran dan Kesehatan2406-74312614-04112019-10-016310110910.32539/JKK.V6I3.77444659ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITISNovriantika Lestari0Department of Pharmacology, Faculty of Medicine and Health Sciences, University of BengkuluLiver fibrosis is a reversible response to a wound healing with marked accumulation of extracellular matrix which caused by injury to the liver. Liver fibrosis can be caused by various factors including alcohol and non-alcohol steatohepatitis. The process of fibrosis serves to localize the inflammation during chronic exposure. The hepatic stem cell (HSC) has a key role in the pathogenesis of liver fibrosis. The HSC activation is characterized by increased profibrogenic mediators including members of the TGF-? superfamily. In order to enable signal transduction, the mediator needs to bind to its receptors. The serine/ threonine kinase receptor is a receptor that binds to the TGF-? superfamily ligand, including TGF-?, BMP, activin and other mediators. The ligand receptor-binding activity will stimulate signal transduction that will translocate into the nucleus and phosphorylate various transcription factors that play a role in cell proliferation, differentiation, or apoptosis. There is currently no standard therapy for liver fibrosis. Based on the central role of the serine/ threonine kinase receptor in the pathogenesis of liver fibrosis, it is thought that the use of serine/ threonine kinase inhibitors is a promising therapy.https://ejournal.unsri.ac.id/index.php/jkk/article/view/7744 |
| spellingShingle | Novriantika Lestari ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITIS Jurnal Kedokteran dan Kesehatan |
| title | ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITIS |
| title_full | ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITIS |
| title_fullStr | ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITIS |
| title_full_unstemmed | ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITIS |
| title_short | ROLE OF SERIN/ THREONINE KINASE INHIBITOR IN THERAPY NON-ALCOHOLIC STEATOHEPATITIS AND ALCOHOLIC HEPATITIS |
| title_sort | role of serin threonine kinase inhibitor in therapy non alcoholic steatohepatitis and alcoholic hepatitis |
| url | https://ejournal.unsri.ac.id/index.php/jkk/article/view/7744 |
| work_keys_str_mv | AT novriantikalestari roleofserinthreoninekinaseinhibitorintherapynonalcoholicsteatohepatitisandalcoholichepatitis |