Sanguisorba officinalis L. enhances the 5-fluorouracil sensitivity and overcomes chemoresistance in 5-fluorouracil-resistant colorectal cancer cells via Ras/MEK/ERK and PI3K/Akt pathways

Sanguisorba officinalis L. enhances the 5-fluorouracil sensitivity and overcomes chemoresistance in 5-fluorouracil-resistant colorectal cancer cells via Ras/MEK/ERK and PI3K/Akt pathways

Sanguisorba officinalis L., a traditional Chinese medicine (TCM) called DiYu (DY) in China, has a strong tradition of utilization as a scorching, blood-cooling, and hemostatic medication, and was used for cancer prevention and treatment due to its potential immune-enhancing and hematological toxicit...

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Bibliographic Details
Main Authors: Weijia Zhang, Ling Ou, Chang Peng, Shuyi Sang, Zhong Feng, Yuanjing Zou, Yuemei Yuan, Hao Li, Guimin Zhang, Meicun Yao
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Sanguisorba officinalis L.
Colorectal cancer
5-Fluorouracil
Drug resistance
Ras/MEK/ERK
PI3K/Akt
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023040057

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