Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potable
Recent evidence suggests that fluoride (F) and arsenic (As) may adversely affect intelligence quotient (IQ) scores. We explore the association between exposure to F and As in drinking water and intelligence in children. Three rural communities in Mexico with contrasting levels of F and As in drinkin...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
2007-01-01
|
| Series: | Cadernos de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2007001600018 |
| _version_ | 1818302530705162240 |
|---|---|
| author | Diana Rocha-Amador Maria Elena Navarro Leticia Carrizales Raúl Morales Jaqueline Calderón |
| author_facet | Diana Rocha-Amador Maria Elena Navarro Leticia Carrizales Raúl Morales Jaqueline Calderón |
| author_sort | Diana Rocha-Amador |
| collection | DOAJ |
| description | Recent evidence suggests that fluoride (F) and arsenic (As) may adversely affect intelligence quotient (IQ) scores. We explore the association between exposure to F and As in drinking water and intelligence in children. Three rural communities in Mexico with contrasting levels of F and As in drinking water were studied: Moctezuma (F 0.8±1.4mg/L; As 5.8±1.3µg/L); Salitral (F 5.3±0.9mg/L; As 169±0.9µg/L) and 5 de Febrero (F 9.4±0.9mg/L; As 194±1.3µg/L). The final study sample consisted of 132 children from 6 to 10 years old. After controlling for confounders, an inverse association was observed between F in urine and Performance, Verbal, and Full IQ scores (beta values = -13, -15.6, -16.9, respectively). Similar results were observed for F in drinking water (beta values = -6.7, -11.2, -10.2, respectively) and As in drinking water (beta values= -4.30, -6.40, -6.15, respectively). The p-values for all cases were < 0.001. A significant association was observed between As in urine and Full IQ scores (beta = -5.72, p = 0.003). These data suggest that children exposed to either F or As have increased risks of reduced IQ scores.<br>Estudios recientes sugieren que el flúor (F) y el arsénico (As) pueden tener efectos adversos sobre el coeficiente intelectual (CI). En este estudio exploramos la asociación entre el F y el As y la inteligencia en niños expuestos a estas sustancias a través del agua. Tres comunidades rurales de México con diferentes niveles de F y As fueron estudiadas: Moctezuma (F 0,8±1,4mg/L; As 5,8±1,3µg/L); Salitral (F 5,3±0,9mg/L; As 169±0,9µg/L) y 5 de Febrero (F 9,4±0,9mg/L; As 194±1,3µg/L). La muestra final fue de 132 niños de 6 a 10 años de edad. Después de controlar por confusores, se obtuvieron asociaciones inversas entre F en orina y las puntuaciones de los CI (Desempeño, Verbal y Total) (valores beta = -13, -15,6, -16,9, respectivamente) p < 0,001 en todos los casos. Resultados similares se obtuvieron con F en agua (valores beta = -6,7, -11,2, -10,2, respectivamente) y con As en agua (valores beta = -4,30, -6,40, -6,15, respectivamente). En todos los casos p < 0,001. Para As en orina, se obtuvo una asociación inversa con las puntuaciones del CI total (beta= -5,72; p = 0,003). Estos datos sugieren que los niños expuestos al F o al As tienen mayor riesgo de tener disminución en las puntuaciones del CI. |
| first_indexed | 2024-12-13T05:40:22Z |
| format | Article |
| id | doaj.art-f88e10925fe04a0ca63b584a41b2b245 |
| institution | Directory Open Access Journal |
| issn | 0102-311X 1678-4464 |
| language | English |
| last_indexed | 2024-12-13T05:40:22Z |
| publishDate | 2007-01-01 |
| publisher | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
| record_format | Article |
| series | Cadernos de Saúde Pública |
| spelling | doaj.art-f88e10925fe04a0ca63b584a41b2b2452022-12-21T23:57:49ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44642007-01-0123S579S58710.1590/S0102-311X2007001600018Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potableDiana Rocha-AmadorMaria Elena NavarroLeticia CarrizalesRaúl MoralesJaqueline CalderónRecent evidence suggests that fluoride (F) and arsenic (As) may adversely affect intelligence quotient (IQ) scores. We explore the association between exposure to F and As in drinking water and intelligence in children. Three rural communities in Mexico with contrasting levels of F and As in drinking water were studied: Moctezuma (F 0.8±1.4mg/L; As 5.8±1.3µg/L); Salitral (F 5.3±0.9mg/L; As 169±0.9µg/L) and 5 de Febrero (F 9.4±0.9mg/L; As 194±1.3µg/L). The final study sample consisted of 132 children from 6 to 10 years old. After controlling for confounders, an inverse association was observed between F in urine and Performance, Verbal, and Full IQ scores (beta values = -13, -15.6, -16.9, respectively). Similar results were observed for F in drinking water (beta values = -6.7, -11.2, -10.2, respectively) and As in drinking water (beta values= -4.30, -6.40, -6.15, respectively). The p-values for all cases were < 0.001. A significant association was observed between As in urine and Full IQ scores (beta = -5.72, p = 0.003). These data suggest that children exposed to either F or As have increased risks of reduced IQ scores.<br>Estudios recientes sugieren que el flúor (F) y el arsénico (As) pueden tener efectos adversos sobre el coeficiente intelectual (CI). En este estudio exploramos la asociación entre el F y el As y la inteligencia en niños expuestos a estas sustancias a través del agua. Tres comunidades rurales de México con diferentes niveles de F y As fueron estudiadas: Moctezuma (F 0,8±1,4mg/L; As 5,8±1,3µg/L); Salitral (F 5,3±0,9mg/L; As 169±0,9µg/L) y 5 de Febrero (F 9,4±0,9mg/L; As 194±1,3µg/L). La muestra final fue de 132 niños de 6 a 10 años de edad. Después de controlar por confusores, se obtuvieron asociaciones inversas entre F en orina y las puntuaciones de los CI (Desempeño, Verbal y Total) (valores beta = -13, -15,6, -16,9, respectivamente) p < 0,001 en todos los casos. Resultados similares se obtuvieron con F en agua (valores beta = -6,7, -11,2, -10,2, respectivamente) y con As en agua (valores beta = -4,30, -6,40, -6,15, respectivamente). En todos los casos p < 0,001. Para As en orina, se obtuvo una asociación inversa con las puntuaciones del CI total (beta= -5,72; p = 0,003). Estos datos sugieren que los niños expuestos al F o al As tienen mayor riesgo de tener disminución en las puntuaciones del CI.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2007001600018FluorurosArsénicoAgua PotableNeurotoxinasInteligenciaFluoridesArsenicPotable WaterNeurotoxinsIntelligence |
| spellingShingle | Diana Rocha-Amador Maria Elena Navarro Leticia Carrizales Raúl Morales Jaqueline Calderón Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potable Cadernos de Saúde Pública Fluoruros Arsénico Agua Potable Neurotoxinas Inteligencia Fluorides Arsenic Potable Water Neurotoxins Intelligence |
| title | Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potable |
| title_full | Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potable |
| title_fullStr | Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potable |
| title_full_unstemmed | Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potable |
| title_short | Decreased intelligence in children and exposure to fluoride and arsenic in drinking water Disminución de la inteligencia en niños y exposición al flúor y arsénico en el agua potable |
| title_sort | decreased intelligence in children and exposure to fluoride and arsenic in drinking water disminucion de la inteligencia en ninos y exposicion al fluor y arsenico en el agua potable |
| topic | Fluoruros Arsénico Agua Potable Neurotoxinas Inteligencia Fluorides Arsenic Potable Water Neurotoxins Intelligence |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2007001600018 |
| work_keys_str_mv | AT dianarochaamador decreasedintelligenceinchildrenandexposuretofluorideandarsenicindrinkingwaterdisminuciondelainteligenciaenninosyexposicionalfluoryarsenicoenelaguapotable AT mariaelenanavarro decreasedintelligenceinchildrenandexposuretofluorideandarsenicindrinkingwaterdisminuciondelainteligenciaenninosyexposicionalfluoryarsenicoenelaguapotable AT leticiacarrizales decreasedintelligenceinchildrenandexposuretofluorideandarsenicindrinkingwaterdisminuciondelainteligenciaenninosyexposicionalfluoryarsenicoenelaguapotable AT raulmorales decreasedintelligenceinchildrenandexposuretofluorideandarsenicindrinkingwaterdisminuciondelainteligenciaenninosyexposicionalfluoryarsenicoenelaguapotable AT jaquelinecalderon decreasedintelligenceinchildrenandexposuretofluorideandarsenicindrinkingwaterdisminuciondelainteligenciaenninosyexposicionalfluoryarsenicoenelaguapotable |