The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.

The involvement of NFAT transcriptional activity suppression in SIRT1-mediated inhibition of COX-2 expression induced by PMA/Ionomycin.

SIRT1, a class III histone deacetylase, acts as a negative regulator for many transcription factors, and plays protective roles in inflammation and atherosclerosis. Transcription factor nuclear factor of activated T cells (NFAT) has been previously shown to play pro-inflammatory roles in endothelial...

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Main Authors: Yu-Yan Jia, Jie Lu, Yue Huang, Guang Liu, Peng Gao, Yan-Zhen Wan, Ran Zhang, Zhu-Qin Zhang, Rui-Feng Yang, Xiaoqiang Tang, Jing Xu, Xu Wang, Hou-Zao Chen, De-Pei Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4032329?pdf=render

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