Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic Adenocarcinoma
Background and purpose: Prostate cancer is the second cause of cancer-related death in men. Early diagnosis and identification of prognostic factors help to predict clinical outcome and select the most effective treatment protocol in each patient. The relationship between CD117 expression and variou...
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-11-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-18999-en.pdf |
| _version_ | 1797561687500390400 |
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| author | Mehdi Rahmanpour Mohammadreza Jalali Nadoushan |
| author_facet | Mehdi Rahmanpour Mohammadreza Jalali Nadoushan |
| author_sort | Mehdi Rahmanpour |
| collection | DOAJ |
| description | Background and purpose: Prostate cancer is the second cause of cancer-related death in men. Early diagnosis and identification of prognostic factors help to predict clinical outcome and select the most effective treatment protocol in each patient. The relationship between CD117 expression and various tumor prognoses has been identified and there is evidence for the role of this marker in prostate cancer pathogenesis. So, the aim of this study was to evaluate CD117 marker expression in prostate benign hyperplasia and adenocarcinoma, and to find its association with Gleason grade.
Materials and methods: In this cross-sectional study, paraffin blocks of tissue samples obtained from 85 patients with prostatic benign hyperplasia and 78 patients with prostatic adenocarcinoma, who referred to Shahid Mostafa Khomeini hospital during 2018 to 2021, were immunohistochemically stained by anti-CD117 antibody. Membranous and cytoplasmic staining in more than 10% of epithelial tumor cells was considered as positive result.
Results: Positive CD117 expression was found in 27.1% of prostatic benign hyperplasia and 50% of prostatic adenocarcinoma samples showed a statistically significant difference (P=0.003). There was no significant relationship between CD117 status expression and primary Gleason grade in prostatic adenocarcinoma samples (P=0.166); however, secondary Gleason grade and total Gleason score had a significant relationship with CD117 expression status (P=0.002 and P=0.017, respectively).
Conclusion: CD117 expression was higher in prostatic carcinoma compared to benign prostatic hyperplasia and its higher expression was associated with higher Gleason grade as one of the most important prognostic factors in prostatic carcinoma |
| first_indexed | 2024-03-10T18:18:27Z |
| format | Article |
| id | doaj.art-f892e67b9f5d4752adcc2062407b5b54 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T18:18:27Z |
| publishDate | 2023-11-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-f892e67b9f5d4752adcc2062407b5b542023-11-20T07:33:34ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-11-0133226172178Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic AdenocarcinomaMehdi Rahmanpour0Mohammadreza Jalali Nadoushan1 Medical Student, Faculty of Medicine, Shahed University, Tehran, Iran Professor, Department of Pathology, Mostafa Khomeini Hospital, Faculty of Medicine, Shahed University, Tehran, Iran Background and purpose: Prostate cancer is the second cause of cancer-related death in men. Early diagnosis and identification of prognostic factors help to predict clinical outcome and select the most effective treatment protocol in each patient. The relationship between CD117 expression and various tumor prognoses has been identified and there is evidence for the role of this marker in prostate cancer pathogenesis. So, the aim of this study was to evaluate CD117 marker expression in prostate benign hyperplasia and adenocarcinoma, and to find its association with Gleason grade. Materials and methods: In this cross-sectional study, paraffin blocks of tissue samples obtained from 85 patients with prostatic benign hyperplasia and 78 patients with prostatic adenocarcinoma, who referred to Shahid Mostafa Khomeini hospital during 2018 to 2021, were immunohistochemically stained by anti-CD117 antibody. Membranous and cytoplasmic staining in more than 10% of epithelial tumor cells was considered as positive result. Results: Positive CD117 expression was found in 27.1% of prostatic benign hyperplasia and 50% of prostatic adenocarcinoma samples showed a statistically significant difference (P=0.003). There was no significant relationship between CD117 status expression and primary Gleason grade in prostatic adenocarcinoma samples (P=0.166); however, secondary Gleason grade and total Gleason score had a significant relationship with CD117 expression status (P=0.002 and P=0.017, respectively). Conclusion: CD117 expression was higher in prostatic carcinoma compared to benign prostatic hyperplasia and its higher expression was associated with higher Gleason grade as one of the most important prognostic factors in prostatic carcinomahttp://jmums.mazums.ac.ir/article-1-18999-en.pdfprostate carcinomagleason gradebenign prostatic hyperplasiacd117 |
| spellingShingle | Mehdi Rahmanpour Mohammadreza Jalali Nadoushan Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic Adenocarcinoma Journal of Mazandaran University of Medical Sciences prostate carcinoma gleason grade benign prostatic hyperplasia cd117 |
| title | Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic Adenocarcinoma |
| title_full | Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic Adenocarcinoma |
| title_fullStr | Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic Adenocarcinoma |
| title_full_unstemmed | Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic Adenocarcinoma |
| title_short | Study of CD117 Expression and Its Relationship with Benign Prostatic Hyperplasia and Gleason Score in Prostatic Adenocarcinoma |
| title_sort | study of cd117 expression and its relationship with benign prostatic hyperplasia and gleason score in prostatic adenocarcinoma |
| topic | prostate carcinoma gleason grade benign prostatic hyperplasia cd117 |
| url | http://jmums.mazums.ac.ir/article-1-18999-en.pdf |
| work_keys_str_mv | AT mehdirahmanpour studyofcd117expressionanditsrelationshipwithbenignprostatichyperplasiaandgleasonscoreinprostaticadenocarcinoma AT mohammadrezajalalinadoushan studyofcd117expressionanditsrelationshipwithbenignprostatichyperplasiaandgleasonscoreinprostaticadenocarcinoma |