Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB

Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB

ABSTRACT Clostridioides difficile infection (CDI) is the leading cause of antibiotic-associated intestinal disease, resulting in severe diarrhea and fatal pseudomembranous colitis. TcdB, one of the essential virulence factors secreted by this bacterium, induces host cell apoptosis through a poorly u...

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Bibliographic Details
Main Authors: Yingxue Li, Wei Xu, Yutian Ren, Hung-Chi Cheung, Panpan Huang, Guneet Kaur, Chih-Jung Kuo, Sean P. McDonough, Susan L. Fubini, Stephen M. Lipkin, Xin Deng, Yung-Fu Chang, Linfeng Huang
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:mBio
Subjects:
C. difficile
TcdB
apoptosis
JUP
HMGB1
RNAi screen
Online Access:https://journals.asm.org/doi/10.1128/mbio.01849-22

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