| Summary: | Background: The present study aims to evaluate the mental health symptoms in the Saudi population during the COVID-19 post-quarantine period and to identify the risk factors associated with the severity of the symptoms. Methods: Anxiety was measured with the 7-item Generalized Anxiety Disorder questionnaire, depression with the 9-item Patient Health Questionnaire, insomnia with the 7-item Insomnia Severity Index, and distress with the 22-item Impact Event Scale-Revised questionnaire. Results: A total of 885 respondents answered the online questionnaires. The majority were women (72.8%), married (67.4%), have children (59.3%), and with high education levels (93.2%). The results showed that a high number of the respondents experienced mild to severe symptoms of anxiety (533; 60.3%), depression (659; 47.5%), insomnia (510; 57.6%), and distress (645; 72.9%). The multivariable logistic analysis demonstrated severe anxiety and insomnia among women (OR = 1.71; 95% CI 1.07–1.98; <i>p</i> < 0.001 and OR = 2.00; 95% CI 1.78–2.35; <i>p</i> = 0.002); severe depression among those under 35 (OR = 2.06; 95% CI 1.97–2.44; <i>p</i> = 0.001; and severe distress among non-Saudi respondents (OR = 1.71; 95% CI 1.09–1.93; <i>p</i> < 0.001). Conclusions: The results might help in establishing precautionary measures for protecting the mental health of the general population during pandemics.
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