Antigen cross-presentation of immune complexes
The ability of dendritic cells (DC) to cross-present tumor antigens has long been a focus of interest of physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway for therapeutic purposes is a better understa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-04-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00140/full |
| _version_ | 1811302404011851776 |
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| author | Barbara ePlatzer Madeleine Monique Stout Edda eFiebiger |
| author_facet | Barbara ePlatzer Madeleine Monique Stout Edda eFiebiger |
| author_sort | Barbara ePlatzer |
| collection | DOAJ |
| description | The ability of dendritic cells (DC) to cross-present tumor antigens has long been a focus of interest of physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway for therapeutic purposes is a better understanding of the mechanisms that underlie the induction of tumor-specific cytotoxic T-lymphocyte (CTL) responses when initiated by DCs via cross-presentation. The ability of humans DC to perform cross-presentation is of utmost interest as this cell type is a main target for cell-based immunotherapy in humans. The outcome of a cross-presentation event is guided by the nature of the antigen, the form of antigen uptake and the subpopulation of DCs that performs presentation. Generally, CD8+ DCs are considered to be the most potent cross-presenting DCs. This paradigm, however, only applies to soluble antigens. During adaptive immune responses, immune complexes form when antibodies interact with their specific epitopes on soluble antigens. Immunoglobulin G (IgG) immune complexes target Fc-gamma receptors on DCs to shuttle exogenous antigens efficiently into the cross-presentation pathway. This receptor mediated cross-presentation pathway is a well-described route for the induction of strong CD8+ T cell responses. IgG-mediated cross-presentation is intriguing because it permits the CD8- DCs, which are commonly considered to be weak cross-presenters, to efficiently cross-present. Engaging multiple DC subtypes for cross-presentation might be a superior strategy to boost CTL responses in vivo. We here summarize our current understanding of how DCs use IgG-complexed antigens for the efficient induction of CTL responses. Because of its importance for human cell therapy, we also review the recent advances in the characterization of cross-presentation properties of human DC subsets. |
| first_indexed | 2024-04-13T07:27:28Z |
| format | Article |
| id | doaj.art-f89486546bd043e1852840cc4918af42 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T07:27:28Z |
| publishDate | 2014-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f89486546bd043e1852840cc4918af422022-12-22T02:56:27ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-04-01510.3389/fimmu.2014.0014082009Antigen cross-presentation of immune complexesBarbara ePlatzer0Madeleine Monique Stout1Edda eFiebiger2Boston Children's Hospital and Harvard Medical SchoolBoston Children's Hospital and Harvard Medical SchoolBoston Children's Hospital and Harvard Medical SchoolThe ability of dendritic cells (DC) to cross-present tumor antigens has long been a focus of interest of physicians, as well as basic scientists, that aim to establish efficient cell-based cancer immune therapy. A prerequisite for exploiting this pathway for therapeutic purposes is a better understanding of the mechanisms that underlie the induction of tumor-specific cytotoxic T-lymphocyte (CTL) responses when initiated by DCs via cross-presentation. The ability of humans DC to perform cross-presentation is of utmost interest as this cell type is a main target for cell-based immunotherapy in humans. The outcome of a cross-presentation event is guided by the nature of the antigen, the form of antigen uptake and the subpopulation of DCs that performs presentation. Generally, CD8+ DCs are considered to be the most potent cross-presenting DCs. This paradigm, however, only applies to soluble antigens. During adaptive immune responses, immune complexes form when antibodies interact with their specific epitopes on soluble antigens. Immunoglobulin G (IgG) immune complexes target Fc-gamma receptors on DCs to shuttle exogenous antigens efficiently into the cross-presentation pathway. This receptor mediated cross-presentation pathway is a well-described route for the induction of strong CD8+ T cell responses. IgG-mediated cross-presentation is intriguing because it permits the CD8- DCs, which are commonly considered to be weak cross-presenters, to efficiently cross-present. Engaging multiple DC subtypes for cross-presentation might be a superior strategy to boost CTL responses in vivo. We here summarize our current understanding of how DCs use IgG-complexed antigens for the efficient induction of CTL responses. Because of its importance for human cell therapy, we also review the recent advances in the characterization of cross-presentation properties of human DC subsets.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00140/fullAnti-tumor immune responsesDC subset functionscell-type specific cross-presentationIgG-complexed antigensFc receptor-mediated antigen uptakeCD8+ T cell priming |
| spellingShingle | Barbara ePlatzer Madeleine Monique Stout Edda eFiebiger Antigen cross-presentation of immune complexes Frontiers in Immunology Anti-tumor immune responses DC subset functions cell-type specific cross-presentation IgG-complexed antigens Fc receptor-mediated antigen uptake CD8+ T cell priming |
| title | Antigen cross-presentation of immune complexes |
| title_full | Antigen cross-presentation of immune complexes |
| title_fullStr | Antigen cross-presentation of immune complexes |
| title_full_unstemmed | Antigen cross-presentation of immune complexes |
| title_short | Antigen cross-presentation of immune complexes |
| title_sort | antigen cross presentation of immune complexes |
| topic | Anti-tumor immune responses DC subset functions cell-type specific cross-presentation IgG-complexed antigens Fc receptor-mediated antigen uptake CD8+ T cell priming |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00140/full |
| work_keys_str_mv | AT barbaraeplatzer antigencrosspresentationofimmunecomplexes AT madeleinemoniquestout antigencrosspresentationofimmunecomplexes AT eddaefiebiger antigencrosspresentationofimmunecomplexes |