Temporal Dimension in Reference Standard Misclassification – A Concept Note
In situations of diagnostic tests studies where the gold standard (GS) test is not absolutely perfect, validity measures of index tests vary in subgroups with varying disease prevalence. This is called reference standard misclassification. Although this is widely known, little is explained about t...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4571/8270_F_(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf |
| _version_ | 1819277945124945920 |
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| author | S A Rizwan Baridalyne Nongkynrih S Lena Charlette Anand Krishnan |
| author_facet | S A Rizwan Baridalyne Nongkynrih S Lena Charlette Anand Krishnan |
| author_sort | S A Rizwan |
| collection | DOAJ |
| description | In situations of diagnostic tests studies where the gold standard (GS) test is not absolutely perfect, validity measures of index tests vary
in subgroups with varying disease prevalence. This is called reference standard misclassification. Although this is widely known, little is
explained about the variations in the performance of index tests when the validity of the GS test itself varies with the time duration of
illness. This article attempts to expand the concept of reference standard misclassification specifically on the effect of time dependence
of diagnostic tests. A brief literature review is also presented which documents the existent knowledge among researchers about the
concept and the methods they usually employ to adjust. A list of solutions which can address the issue has also been discussed to enable
researchers to design and analyse diagnostic test studies in better ways. |
| first_indexed | 2024-12-24T00:04:10Z |
| format | Article |
| id | doaj.art-f895a574610b47ee8ca63d66fb6adb38 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-24T00:04:10Z |
| publishDate | 2014-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-f895a574610b47ee8ca63d66fb6adb382022-12-21T17:25:04ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-07-0187JE01JE0510.7860/JCDR/2014/8270.4571Temporal Dimension in Reference Standard Misclassification – A Concept NoteS A Rizwan0Baridalyne Nongkynrih1S Lena Charlette2Anand Krishnan3Junior Resident, Department of Community Medicine, All India Institute of Medical Science, New Delhi, India.Additional Professor, Department of Community Medicine, All India Institute of Medical Science, New Delhi, India.Junior Resident, Department of Community Medicine, All India Institute of Medical Science, New Delhi, India.Professor, Department of Community Medicine, All India Institute of Medical Science, New Delhi, India.In situations of diagnostic tests studies where the gold standard (GS) test is not absolutely perfect, validity measures of index tests vary in subgroups with varying disease prevalence. This is called reference standard misclassification. Although this is widely known, little is explained about the variations in the performance of index tests when the validity of the GS test itself varies with the time duration of illness. This article attempts to expand the concept of reference standard misclassification specifically on the effect of time dependence of diagnostic tests. A brief literature review is also presented which documents the existent knowledge among researchers about the concept and the methods they usually employ to adjust. A list of solutions which can address the issue has also been discussed to enable researchers to design and analyse diagnostic test studies in better ways.https://jcdr.net/articles/PDF/4571/8270_F_(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdfantibody testsblood cultureimperfect gsreference standard misclassificationsensitivityspecificitytime dependencetyphoid fevervalidity |
| spellingShingle | S A Rizwan Baridalyne Nongkynrih S Lena Charlette Anand Krishnan Temporal Dimension in Reference Standard Misclassification – A Concept Note Journal of Clinical and Diagnostic Research antibody tests blood culture imperfect gs reference standard misclassification sensitivity specificity time dependence typhoid fever validity |
| title | Temporal Dimension in Reference Standard Misclassification – A Concept Note |
| title_full | Temporal Dimension in Reference Standard Misclassification – A Concept Note |
| title_fullStr | Temporal Dimension in Reference Standard Misclassification – A Concept Note |
| title_full_unstemmed | Temporal Dimension in Reference Standard Misclassification – A Concept Note |
| title_short | Temporal Dimension in Reference Standard Misclassification – A Concept Note |
| title_sort | temporal dimension in reference standard misclassification a concept note |
| topic | antibody tests blood culture imperfect gs reference standard misclassification sensitivity specificity time dependence typhoid fever validity |
| url | https://jcdr.net/articles/PDF/4571/8270_F_(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf |
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