Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage
The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors of oligodendrocytes (OPCs), the glial cells of the central n...
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-09-01
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| Series: | Journal of Developmental Biology |
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| Online Access: | http://www.mdpi.com/2221-3759/4/3/28 |
| _version_ | 1811261775878815744 |
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| author | Elisabeth Traiffort Mary Zakaria Yousra Laouarem Julien Ferent |
| author_facet | Elisabeth Traiffort Mary Zakaria Yousra Laouarem Julien Ferent |
| author_sort | Elisabeth Traiffort |
| collection | DOAJ |
| description | The Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors of oligodendrocytes (OPCs), the glial cells of the central nervous system which after maturation are responsible for axon myelination. In accordance with the requirement for Hedgehog signaling in ventral patterning, the earliest identifiable cells in the oligodendrocyte lineage are derived from the ventral ventricular zone of the developing spinal cord and brain. Here, we present the current knowledge about the involvement of Hedgehog signaling in the strict spatial and temporal regulation which characterizes the initiation and progression of the oligodendrocyte lineage. We notably describe the ability of the Hedgehog signaling to tightly orchestrate the appearance of specific combinations of genes in concert with other pathways. We document the molecular mechanisms controlling Hedgehog temporal activity during OPC specification. The contribution of the pathway to aspects of OPC development different from their specification is also highlighted especially in the optic nerve. Finally, we report the data demonstrating that Hedgehog signaling-dependency is not a universal situation for oligodendrocyte generation as evidenced in the dorsal spinal cord in contrast to the dorsal forebrain. |
| first_indexed | 2024-04-12T19:11:54Z |
| format | Article |
| id | doaj.art-f896b4cf1d4e427499a6bc7ddaad829d |
| institution | Directory Open Access Journal |
| issn | 2221-3759 |
| language | English |
| last_indexed | 2024-04-12T19:11:54Z |
| publishDate | 2016-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Developmental Biology |
| spelling | doaj.art-f896b4cf1d4e427499a6bc7ddaad829d2022-12-22T03:19:52ZengMDPI AGJournal of Developmental Biology2221-37592016-09-01432810.3390/jdb4030028jdb4030028Hedgehog: A Key Signaling in the Development of the Oligodendrocyte LineageElisabeth Traiffort0Mary Zakaria1Yousra Laouarem2Julien Ferent3Neuroprotective, Neuroregenerative and Remyelinating Small Molecules’ U1195, INSERM—Université Paris-Sud, Université Paris-Saclay, 80 rue du Général Leclerc, Kremlin-Bicêtre F-94276, FranceNeuroprotective, Neuroregenerative and Remyelinating Small Molecules’ U1195, INSERM—Université Paris-Sud, Université Paris-Saclay, 80 rue du Général Leclerc, Kremlin-Bicêtre F-94276, FranceNeuroprotective, Neuroregenerative and Remyelinating Small Molecules’ U1195, INSERM—Université Paris-Sud, Université Paris-Saclay, 80 rue du Général Leclerc, Kremlin-Bicêtre F-94276, FranceIRCM, Molecular Biology of Neural Development, 110 Pine Avenue West, Montreal, QC H2W 1R7, CanadaThe Hedgehog morphogen aroused an enormous interest since it was characterized as an essential signal for ventral patterning of the spinal cord two decades ago. The pathway is notably implicated in the initial appearance of the progenitors of oligodendrocytes (OPCs), the glial cells of the central nervous system which after maturation are responsible for axon myelination. In accordance with the requirement for Hedgehog signaling in ventral patterning, the earliest identifiable cells in the oligodendrocyte lineage are derived from the ventral ventricular zone of the developing spinal cord and brain. Here, we present the current knowledge about the involvement of Hedgehog signaling in the strict spatial and temporal regulation which characterizes the initiation and progression of the oligodendrocyte lineage. We notably describe the ability of the Hedgehog signaling to tightly orchestrate the appearance of specific combinations of genes in concert with other pathways. We document the molecular mechanisms controlling Hedgehog temporal activity during OPC specification. The contribution of the pathway to aspects of OPC development different from their specification is also highlighted especially in the optic nerve. Finally, we report the data demonstrating that Hedgehog signaling-dependency is not a universal situation for oligodendrocyte generation as evidenced in the dorsal spinal cord in contrast to the dorsal forebrain.http://www.mdpi.com/2221-3759/4/3/28oligodendrocyteneural tubeforebrainoptic nerveSmoothenedPatchedGli |
| spellingShingle | Elisabeth Traiffort Mary Zakaria Yousra Laouarem Julien Ferent Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage Journal of Developmental Biology oligodendrocyte neural tube forebrain optic nerve Smoothened Patched Gli |
| title | Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage |
| title_full | Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage |
| title_fullStr | Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage |
| title_full_unstemmed | Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage |
| title_short | Hedgehog: A Key Signaling in the Development of the Oligodendrocyte Lineage |
| title_sort | hedgehog a key signaling in the development of the oligodendrocyte lineage |
| topic | oligodendrocyte neural tube forebrain optic nerve Smoothened Patched Gli |
| url | http://www.mdpi.com/2221-3759/4/3/28 |
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