New Insights into Ion Channels: Predicting hERG-Drug Interactions

New Insights into Ion Channels: Predicting hERG-Drug Interactions

Drug-induced long QT syndrome can be a very dangerous side effect of existing and developmental drugs. In this work, a model proposed two decades ago addressing the ion specificity of potassium channels is extended to the human ether-à-gogo gene (hERG). hERG encodes the protein that assembles into t...

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Bibliographic Details
Main Author:	Michael Fitzpatrick Wempe
Format:	Article
Language:	English
Published:	MDPI AG 2022-09-01
Series:	International Journal of Molecular Sciences
Subjects:	potassium channel human ether-à-gogo-related gene (hERG) structure–activity relationships (SAR) ab initio calculations drug development long QT syndrome
Online Access:	https://www.mdpi.com/1422-0067/23/18/10732

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