High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer
Background: The literature data regarding colon cancer patients with liver-only metastases (CLM) show that NLR determined before metastasectomy is a prognostic marker of shorter relapse-free survival (RFS), but no results has been reported to date for rectal cancer patients with liver-only metastase...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Pathology and Oncology Research |
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| Online Access: | https://www.por-journal.com/articles/10.3389/pore.2022.1610315/full |
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| author | Nándor Polk Barna Budai Erika Hitre Attila Patócs Attila Patócs Attila Patócs Tamás Mersich |
| author_facet | Nándor Polk Barna Budai Erika Hitre Attila Patócs Attila Patócs Attila Patócs Tamás Mersich |
| author_sort | Nándor Polk |
| collection | DOAJ |
| description | Background: The literature data regarding colon cancer patients with liver-only metastases (CLM) show that NLR determined before metastasectomy is a prognostic marker of shorter relapse-free survival (RFS), but no results has been reported to date for rectal cancer patients with liver-only metastases (RLM). This study aimed to investigate the NLR and SII in CLM and RLM.Methods: Relapse-free (RFS) and overall survival (OS) were evaluated in 67 CLM and 103 RLM patients with a median follow-up of 46.5 and 59.8 months, respectively. Pre- and/or postoperative chemotherapy ± targeted treatment was applied in 96% and 87% of CLM and RLM patients, respectively. The cut-off level for hematologic parameters were determined by receiver operating characteristic (ROC) analysis. Univariate analysis was performed by Kaplan-Meier method and log rank test. For multivariate analysis Cox regression was applied.Results: In univariate analysis low NLR (cut-off 2) and SII (535) were predictors of longer RFS in case of CLM (p < 0.01). In contrast, for RLM high NLR (2.42) and SII (792) were predictors of longer RFS (p < 0.001). For RLM both NLR and SII proved to be independent markers of RFS (HR 0.66 (95% CI 0.52–0.84) and 0.73 (0.57–0.91), respectively) and OS (0.76 (0.58–0.99) and 0.66 (0.5–0.87), respectively). Only NLR (1.44 (1.04–1.99)) was independent marker of RFS for CLM. The preoperative treatment has not influenced the role of NLR or SII.Conclusion: In contrast to CLM, in RLM the high NLR or SII determined before metastasectomy proved to be independent prognostic factors of longer RFS and OS. |
| first_indexed | 2024-04-24T12:59:12Z |
| format | Article |
| id | doaj.art-f8997d713a164e589099128b0af2f694 |
| institution | Directory Open Access Journal |
| issn | 1532-2807 |
| language | English |
| last_indexed | 2024-04-24T12:59:12Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Pathology and Oncology Research |
| spelling | doaj.art-f8997d713a164e589099128b0af2f6942024-04-05T16:34:19ZengFrontiers Media S.A.Pathology and Oncology Research1532-28072022-04-012810.3389/pore.2022.16103151610315High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal CancerNándor Polk0Barna Budai1Erika Hitre2Attila Patócs3Attila Patócs4Attila Patócs5Tamás Mersich6Departmet of Visceral Surgery, National Institute of Oncology, Budapest, HungaryDepartment of Molecular Genetics, National Institute of Oncology, Budapest, HungaryMedical Oncology and Clinical Pharmacology “B” Department, National Institute of Oncology, Budapest, HungaryDepartment of Laboratory Medicine, Semmelweis University, Budapest, HungaryDepartment of Molecular Genetics, National Institute of Oncology, Budapest, HungaryClinical Central Laboratory, National Institute of Oncology, Budapest, HungaryDepartmet of Visceral Surgery, National Institute of Oncology, Budapest, HungaryBackground: The literature data regarding colon cancer patients with liver-only metastases (CLM) show that NLR determined before metastasectomy is a prognostic marker of shorter relapse-free survival (RFS), but no results has been reported to date for rectal cancer patients with liver-only metastases (RLM). This study aimed to investigate the NLR and SII in CLM and RLM.Methods: Relapse-free (RFS) and overall survival (OS) were evaluated in 67 CLM and 103 RLM patients with a median follow-up of 46.5 and 59.8 months, respectively. Pre- and/or postoperative chemotherapy ± targeted treatment was applied in 96% and 87% of CLM and RLM patients, respectively. The cut-off level for hematologic parameters were determined by receiver operating characteristic (ROC) analysis. Univariate analysis was performed by Kaplan-Meier method and log rank test. For multivariate analysis Cox regression was applied.Results: In univariate analysis low NLR (cut-off 2) and SII (535) were predictors of longer RFS in case of CLM (p < 0.01). In contrast, for RLM high NLR (2.42) and SII (792) were predictors of longer RFS (p < 0.001). For RLM both NLR and SII proved to be independent markers of RFS (HR 0.66 (95% CI 0.52–0.84) and 0.73 (0.57–0.91), respectively) and OS (0.76 (0.58–0.99) and 0.66 (0.5–0.87), respectively). Only NLR (1.44 (1.04–1.99)) was independent marker of RFS for CLM. The preoperative treatment has not influenced the role of NLR or SII.Conclusion: In contrast to CLM, in RLM the high NLR or SII determined before metastasectomy proved to be independent prognostic factors of longer RFS and OS.https://www.por-journal.com/articles/10.3389/pore.2022.1610315/fullneutrophil-to-lymphocyte ratioliver-only metastases of rectal cancermetastasectomyrelapse-free survivalsystemic immune-inflammation indexliver-only metastases of colon cancer |
| spellingShingle | Nándor Polk Barna Budai Erika Hitre Attila Patócs Attila Patócs Attila Patócs Tamás Mersich High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer Pathology and Oncology Research neutrophil-to-lymphocyte ratio liver-only metastases of rectal cancer metastasectomy relapse-free survival systemic immune-inflammation index liver-only metastases of colon cancer |
| title | High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer |
| title_full | High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer |
| title_fullStr | High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer |
| title_full_unstemmed | High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer |
| title_short | High Neutrophil-To-Lymphocyte Ratio (NLR) and Systemic Immune-Inflammation Index (SII) Are Markers of Longer Survival After Metastasectomy of Patients With Liver-Only Metastasis of Rectal Cancer |
| title_sort | high neutrophil to lymphocyte ratio nlr and systemic immune inflammation index sii are markers of longer survival after metastasectomy of patients with liver only metastasis of rectal cancer |
| topic | neutrophil-to-lymphocyte ratio liver-only metastases of rectal cancer metastasectomy relapse-free survival systemic immune-inflammation index liver-only metastases of colon cancer |
| url | https://www.por-journal.com/articles/10.3389/pore.2022.1610315/full |
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