Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily

Structural Conservation and Functional Diversity of the Poxvirus Immune Evasion (PIE) Domain Superfamily

Poxviruses encode a broad array of proteins that serve to undermine host immune defenses. Structural analysis of four of these seemingly unrelated proteins revealed the recurrent use of a conserved beta-sandwich fold that has not been observed in any eukaryotic or prokaryotic protein. Herein we prop...

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Bibliographic Details
Main Authors: Christopher A. Nelson, Megan L. Epperson, Sukrit Singh, Jabari I. Elliott, Daved H. Fremont
Format: Article
Language:English
Published: MDPI AG 2015-08-01
Series:Viruses
Subjects:
poxvirus
PIE domain
SECRET domain
viral immune evasion
chemokine and cytokine decoy receptors
Online Access:http://www.mdpi.com/1999-4915/7/9/2848

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