Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment.
Although the clinical range of interventions for coronary arteries is about 2 to 5 mm, the range of diameters of peripheral vasculature is significantly larger (about 10 mm for human iliac artery). When the vessel diameter is increased, the spacing between excitation electrodes on a conductance sizi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5207717?pdf=render |
| _version_ | 1811344664842731520 |
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| author | Hyo Won Choi Zachary C Berwick Matthew S Sulkin Christopher D Owens Ghassan S Kassab |
| author_facet | Hyo Won Choi Zachary C Berwick Matthew S Sulkin Christopher D Owens Ghassan S Kassab |
| author_sort | Hyo Won Choi |
| collection | DOAJ |
| description | Although the clinical range of interventions for coronary arteries is about 2 to 5 mm, the range of diameters of peripheral vasculature is significantly larger (about 10 mm for human iliac artery). When the vessel diameter is increased, the spacing between excitation electrodes on a conductance sizing device must also increase to accommodate the greater range of vessel diameters. The increase in the excitation electrodes distance, however, causes higher parallel conductance or current losses outside of artery lumen. We have previously shown that the conductance catheter/guidewire excitation electrode distances affects the measurement accuracy for the peripheral artery lumen sizing. Here, we propose a simple solution that varies the detection electrode distances to compensate for parallel conductance losses. Computational models were constructed to simulate the conductance guidewire with various electrodes spacing combinations over a range of peripheral artery lumen diameters and surrounding tissue electrical conductivities. The results demonstrate that the measurement accuracy may be significantly improved by increased detection spacing. Specifically, an optimally configured detection/excitation spacing (i.e., 5-5-5 or an equidistant electrode interval with a detection-to-excitation spacing ratio of 0.3) was shown to accurately predict the lumen diameter (i.e., -10% < error < 10%) over a broad range of peripheral artery dimensions (4 mm < diameter < 10 mm). The computational results were substantiated with both ex-vivo and in-vivo measurements of peripheral arteries. The present results support the accuracy of the conductance technique for measurement of peripheral reference vessel diameter. |
| first_indexed | 2024-04-13T19:50:35Z |
| format | Article |
| id | doaj.art-f89f1cc799e3458cb52fe7cae4688580 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T19:50:35Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f89f1cc799e3458cb52fe7cae46885802022-12-22T02:32:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01121e016888610.1371/journal.pone.0168886Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment.Hyo Won ChoiZachary C BerwickMatthew S SulkinChristopher D OwensGhassan S KassabAlthough the clinical range of interventions for coronary arteries is about 2 to 5 mm, the range of diameters of peripheral vasculature is significantly larger (about 10 mm for human iliac artery). When the vessel diameter is increased, the spacing between excitation electrodes on a conductance sizing device must also increase to accommodate the greater range of vessel diameters. The increase in the excitation electrodes distance, however, causes higher parallel conductance or current losses outside of artery lumen. We have previously shown that the conductance catheter/guidewire excitation electrode distances affects the measurement accuracy for the peripheral artery lumen sizing. Here, we propose a simple solution that varies the detection electrode distances to compensate for parallel conductance losses. Computational models were constructed to simulate the conductance guidewire with various electrodes spacing combinations over a range of peripheral artery lumen diameters and surrounding tissue electrical conductivities. The results demonstrate that the measurement accuracy may be significantly improved by increased detection spacing. Specifically, an optimally configured detection/excitation spacing (i.e., 5-5-5 or an equidistant electrode interval with a detection-to-excitation spacing ratio of 0.3) was shown to accurately predict the lumen diameter (i.e., -10% < error < 10%) over a broad range of peripheral artery dimensions (4 mm < diameter < 10 mm). The computational results were substantiated with both ex-vivo and in-vivo measurements of peripheral arteries. The present results support the accuracy of the conductance technique for measurement of peripheral reference vessel diameter.http://europepmc.org/articles/PMC5207717?pdf=render |
| spellingShingle | Hyo Won Choi Zachary C Berwick Matthew S Sulkin Christopher D Owens Ghassan S Kassab Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment. PLoS ONE |
| title | Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment. |
| title_full | Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment. |
| title_fullStr | Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment. |
| title_full_unstemmed | Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment. |
| title_short | Optimization of Peripheral Vascular Sizing with Conductance Guidewire: Theory and Experiment. |
| title_sort | optimization of peripheral vascular sizing with conductance guidewire theory and experiment |
| url | http://europepmc.org/articles/PMC5207717?pdf=render |
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