The energy landscape analysis of cancer mutations in protein kinases.

The growing interest in quantifying the molecular basis of protein kinase activation and allosteric regulation by cancer mutations has fueled computational studies of allosteric signaling in protein kinases. In the present study, we combined computer simulations and the energy landscape analysis of...

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Detalhes bibliográficos
Principais autores: Anshuman Dixit, Gennady M Verkhivker
Formato: Artigo
Idioma:English
Publicado em: Public Library of Science (PLoS) 2011-01-01
coleção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3188581?pdf=render