Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUH
Objective: Hemolytic disease of the fetus and newborn (HDFN) caused by irregular antibodies is a rare, but possibly life-threatening condition. We report a case of severe intrauterine hemolysis caused by anti-E alloimmunization, and review 16 cases in the past 15 years of our hospital. Case report:...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-09-01
|
| Series: | Taiwanese Journal of Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455922002273 |
| _version_ | 1811275107873587200 |
|---|---|
| author | Ming-Ta Chuang Chiung-Hsin Chang |
| author_facet | Ming-Ta Chuang Chiung-Hsin Chang |
| author_sort | Ming-Ta Chuang |
| collection | DOAJ |
| description | Objective: Hemolytic disease of the fetus and newborn (HDFN) caused by irregular antibodies is a rare, but possibly life-threatening condition. We report a case of severe intrauterine hemolysis caused by anti-E alloimmunization, and review 16 cases in the past 15 years of our hospital. Case report: A woman with gestational age 28 weeks and 5 days, received emergent Cesarean section because of fetal distress. The baby was expired at the next day after delivery and the comprehensive study showed severe anemia and alloimmunization related hemolysis caused by anti-E due to high antibody titer (1: 4096). Conclusion: Anti-E antibody is one of the most common non-Rhesus D antibodies in the pathogenesis of HDFN, but rarely leads to severe hemolysis. However, our case has the highest reported anti-E titer in HDFN and is the first case of mortality during the past 15 years in NCKUH. |
| first_indexed | 2024-04-12T23:32:10Z |
| format | Article |
| id | doaj.art-f8a0ef35fc0e4fcead314d2e9469f2af |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-04-12T23:32:10Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-f8a0ef35fc0e4fcead314d2e9469f2af2022-12-22T03:12:15ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592022-09-01615896899Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUHMing-Ta Chuang0Chiung-Hsin Chang1Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanCorresponding author. Department of Obstetrics & Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, No.138, Sheng Li Road, Tainan, 704, Taiwan. Fax: +886 6 276 6185.; Department of Obstetrics and Gynecology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, TaiwanObjective: Hemolytic disease of the fetus and newborn (HDFN) caused by irregular antibodies is a rare, but possibly life-threatening condition. We report a case of severe intrauterine hemolysis caused by anti-E alloimmunization, and review 16 cases in the past 15 years of our hospital. Case report: A woman with gestational age 28 weeks and 5 days, received emergent Cesarean section because of fetal distress. The baby was expired at the next day after delivery and the comprehensive study showed severe anemia and alloimmunization related hemolysis caused by anti-E due to high antibody titer (1: 4096). Conclusion: Anti-E antibody is one of the most common non-Rhesus D antibodies in the pathogenesis of HDFN, but rarely leads to severe hemolysis. However, our case has the highest reported anti-E titer in HDFN and is the first case of mortality during the past 15 years in NCKUH.http://www.sciencedirect.com/science/article/pii/S1028455922002273Hemolytic disease of the fetus and newbornIrregular antibodiesAnti-E |
| spellingShingle | Ming-Ta Chuang Chiung-Hsin Chang Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUH Taiwanese Journal of Obstetrics & Gynecology Hemolytic disease of the fetus and newborn Irregular antibodies Anti-E |
| title | Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUH |
| title_full | Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUH |
| title_fullStr | Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUH |
| title_full_unstemmed | Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUH |
| title_short | Hemolytic disease of the fetus and newborn caused by irregular antibody: A mortality case report and case series during the past 15 years in NCKUH |
| title_sort | hemolytic disease of the fetus and newborn caused by irregular antibody a mortality case report and case series during the past 15 years in nckuh |
| topic | Hemolytic disease of the fetus and newborn Irregular antibodies Anti-E |
| url | http://www.sciencedirect.com/science/article/pii/S1028455922002273 |
| work_keys_str_mv | AT mingtachuang hemolyticdiseaseofthefetusandnewborncausedbyirregularantibodyamortalitycasereportandcaseseriesduringthepast15yearsinnckuh AT chiunghsinchang hemolyticdiseaseofthefetusandnewborncausedbyirregularantibodyamortalitycasereportandcaseseriesduringthepast15yearsinnckuh |