Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity

Regression Modeling of the Antioxidant-to-Nephroprotective Relation Shows the Pivotal Role of Oxidative Stress in Cisplatin Nephrotoxicity

The clinical utility of the chemotherapeutic drug cisplatin is significantly limited by its nephrotoxicity, which is characterized by electrolytic disorders, glomerular filtration rate decline, and azotemia. These alterations are consequences of a primary tubulopathy causing injury to proximal and d...

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Bibliographic Details
Main Authors: Alfredo G. Casanova, Mykola Harvat, Laura Vicente-Vicente, Óscar J. Pellicer-Valero, Ana I. Morales, Francisco J. López-Hernández, José D. Martín-Guerrero
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Antioxidants
Subjects:
cisplatin
nephrotoxicity
prevention
antioxidants
preclinical
linear fit
Online Access:https://www.mdpi.com/2076-3921/10/9/1355

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