Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation
ABSTRACTThe gut microbiome is known as the tenth system of the human body that plays a vital role in the intersection between health and disease. The considerable inter-individual variability in gut microbiota poses both challenges and great prospects in promoting precision medicine in cardiovascula...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2323237 |
| _version_ | 1797293829680791552 |
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| author | Bozhong Shi Haoyu Li Xiaomin He |
| author_facet | Bozhong Shi Haoyu Li Xiaomin He |
| author_sort | Bozhong Shi |
| collection | DOAJ |
| description | ABSTRACTThe gut microbiome is known as the tenth system of the human body that plays a vital role in the intersection between health and disease. The considerable inter-individual variability in gut microbiota poses both challenges and great prospects in promoting precision medicine in cardiovascular diseases (CVDs). In this review, based on the development, evolution, and influencing factors of gut microbiota in a full life circle, we summarized the recent advances on the characteristic alteration in gut microbiota in CVDs throughout different life stages, and depicted their pathological links in mechanism, as well as the highlight achievements of targeting gut microbiota in CVDs prevention, diagnosis and treatment. Personalized strategies could be tailored according to gut microbiota characteristics in different life stages, including gut microbiota-blood metabolites combined prediction and diagnosis, dietary interventions, lifestyle improvements, probiotic or prebiotic supplements. However, to fulfill the promise of a lifelong cardiovascular health, more mechanism studies should progress from correlation to causality and decipher novel mechanisms linking specific microbes and CVDs. It is also promising to use the burgeoning artificial intelligence and machine learning to target gut microbiota for developing diagnosis system and screening for new therapeutic interventions. |
| first_indexed | 2024-03-07T21:21:31Z |
| format | Article |
| id | doaj.art-f8a2b453575d46f08af46c2b314b2e4e |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-03-07T21:21:31Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-f8a2b453575d46f08af46c2b314b2e4e2024-02-27T14:11:21ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2323237Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulationBozhong Shi0Haoyu Li1Xiaomin He2Department of Cardiothoracic Surgery, Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiothoracic Surgery, Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Cardiothoracic Surgery, Shanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaABSTRACTThe gut microbiome is known as the tenth system of the human body that plays a vital role in the intersection between health and disease. The considerable inter-individual variability in gut microbiota poses both challenges and great prospects in promoting precision medicine in cardiovascular diseases (CVDs). In this review, based on the development, evolution, and influencing factors of gut microbiota in a full life circle, we summarized the recent advances on the characteristic alteration in gut microbiota in CVDs throughout different life stages, and depicted their pathological links in mechanism, as well as the highlight achievements of targeting gut microbiota in CVDs prevention, diagnosis and treatment. Personalized strategies could be tailored according to gut microbiota characteristics in different life stages, including gut microbiota-blood metabolites combined prediction and diagnosis, dietary interventions, lifestyle improvements, probiotic or prebiotic supplements. However, to fulfill the promise of a lifelong cardiovascular health, more mechanism studies should progress from correlation to causality and decipher novel mechanisms linking specific microbes and CVDs. It is also promising to use the burgeoning artificial intelligence and machine learning to target gut microbiota for developing diagnosis system and screening for new therapeutic interventions.https://www.tandfonline.com/doi/10.1080/19490976.2024.2323237Cardiovascular diseasesgut microbiotalifelong careprecision medicine |
| spellingShingle | Bozhong Shi Haoyu Li Xiaomin He Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation Gut Microbes Cardiovascular diseases gut microbiota lifelong care precision medicine |
| title | Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation |
| title_full | Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation |
| title_fullStr | Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation |
| title_full_unstemmed | Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation |
| title_short | Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation |
| title_sort | advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation |
| topic | Cardiovascular diseases gut microbiota lifelong care precision medicine |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2323237 |
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