Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximab
BackgroundThe disease activity status and behavior of Crohn’s disease (CD) can reflect the severity of the disease, and changes in body composition are common in CD patients.AimsThe aim of this study was to investigate the relationship between body composition parameters and disease severity in CD p...
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1251448/full |
| _version_ | 1797739312908861440 |
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| author | Wuli Tang Wuli Tang Wuli Tang Wuli Tang Gang Xie Junlin Li Wei Tan Rongqi Yi Ling Yang Lingqin Zhang Jiaxing Deng Yue Zhang Kang Li Kang Li Kang Li Kang Li |
| author_facet | Wuli Tang Wuli Tang Wuli Tang Wuli Tang Gang Xie Junlin Li Wei Tan Rongqi Yi Ling Yang Lingqin Zhang Jiaxing Deng Yue Zhang Kang Li Kang Li Kang Li Kang Li |
| author_sort | Wuli Tang |
| collection | DOAJ |
| description | BackgroundThe disease activity status and behavior of Crohn’s disease (CD) can reflect the severity of the disease, and changes in body composition are common in CD patients.AimsThe aim of this study was to investigate the relationship between body composition parameters and disease severity in CD patients treated with infliximab (IFX).MethodsPatients with CD assessed with the simple endoscopic score (SES-CD) and were treated with IFX were retrospectively collected, and body composition parameters at the level of the 3rd lumbar vertebrae were calculated from computed tomography (CT) scans of the patients. The correlation of patients’ body composition parameters with disease activity status and disease behavior was analyzed, and the diagnostic value of the relevant parameters was assessed using receiver operating characteristic (ROC) curves.ResultsA total of 106 patients were included in this study. There were significant differences in the subcutaneous adiposity index (SAI) (p = 0.010), the visceral adiposity index (VAI) (p < 0.001), the skeletal muscle mass index (SMI) (p < 0.001), and decreased skeletal muscle mass (p < 0.001) among patients with different activity status. After Spearman and multivariate regression analysis, SAI (p = 0.006 and p = 0.001), VAI (p < 0.001 and p < 0.001), and SMI (p < 0.001and p = 0.007) were identified as independent correlates of disease activity status (both disease activity and moderate-to-severe activity), with disease activity status independently positively correlated with SAI and SMI and independently negatively correlated with VAI. In determining the disease activity and moderate-to-severe activity status, SMI performed best relative to SAI and VAI, with areas under the ROC curve of 0.865 and 0.801, respectively. SAI (p = 0.015), SMI (p = 0.011) and decreased skeletal muscle mass (p = 0.027) were significantly different between different disease behavior groups (inflammatory disease behavior group, complex disease behavior group) but were not independent correlates (p > 0.05).ConclusionBody composition parameters of CD patients treated with IFX correlate with the endoscopic disease severity, and SMI can be used as a reliable indicator of disease activity status. |
| first_indexed | 2024-03-12T13:56:25Z |
| format | Article |
| id | doaj.art-f8a361a2e97341158ffea847515855f6 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-12T13:56:25Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-f8a361a2e97341158ffea847515855f62023-08-22T15:25:49ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-08-011010.3389/fnut.2023.12514481251448Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximabWuli Tang0Wuli Tang1Wuli Tang2Wuli Tang3Gang Xie4Junlin Li5Wei Tan6Rongqi Yi7Ling Yang8Lingqin Zhang9Jiaxing Deng10Yue Zhang11Kang Li12Kang Li13Kang Li14Kang Li15Chongqing Medical University, Chongqing, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaChongqing School, University of Chinese Academy of Science, Chongqing, ChinaDepartment of Radiology, Chongqing General Hospital, Chongqing, ChinaDepartment of Radiology, The Third People’s Hospital of Chengdu, Chengdu, ChinaDepartment of Radiology, Chongqing General Hospital, Chongqing, ChinaDepartment of Gastroenterology, Chongqing General Hospital, Chongqing, ChinaDepartment of Radiology, Chongqing General Hospital, Chongqing, ChinaDepartment of Radiology, Chongqing General Hospital, Chongqing, ChinaDepartment of Radiology, Chongqing General Hospital, Chongqing, ChinaDepartment of General Medicine, Chongqing General Hospital, Chongqing, ChinaDepartment of Radiology, Chongqing General Hospital, Chongqing, ChinaChongqing Medical University, Chongqing, ChinaChongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing, ChinaChongqing School, University of Chinese Academy of Science, Chongqing, ChinaDepartment of Radiology, Chongqing General Hospital, Chongqing, ChinaBackgroundThe disease activity status and behavior of Crohn’s disease (CD) can reflect the severity of the disease, and changes in body composition are common in CD patients.AimsThe aim of this study was to investigate the relationship between body composition parameters and disease severity in CD patients treated with infliximab (IFX).MethodsPatients with CD assessed with the simple endoscopic score (SES-CD) and were treated with IFX were retrospectively collected, and body composition parameters at the level of the 3rd lumbar vertebrae were calculated from computed tomography (CT) scans of the patients. The correlation of patients’ body composition parameters with disease activity status and disease behavior was analyzed, and the diagnostic value of the relevant parameters was assessed using receiver operating characteristic (ROC) curves.ResultsA total of 106 patients were included in this study. There were significant differences in the subcutaneous adiposity index (SAI) (p = 0.010), the visceral adiposity index (VAI) (p < 0.001), the skeletal muscle mass index (SMI) (p < 0.001), and decreased skeletal muscle mass (p < 0.001) among patients with different activity status. After Spearman and multivariate regression analysis, SAI (p = 0.006 and p = 0.001), VAI (p < 0.001 and p < 0.001), and SMI (p < 0.001and p = 0.007) were identified as independent correlates of disease activity status (both disease activity and moderate-to-severe activity), with disease activity status independently positively correlated with SAI and SMI and independently negatively correlated with VAI. In determining the disease activity and moderate-to-severe activity status, SMI performed best relative to SAI and VAI, with areas under the ROC curve of 0.865 and 0.801, respectively. SAI (p = 0.015), SMI (p = 0.011) and decreased skeletal muscle mass (p = 0.027) were significantly different between different disease behavior groups (inflammatory disease behavior group, complex disease behavior group) but were not independent correlates (p > 0.05).ConclusionBody composition parameters of CD patients treated with IFX correlate with the endoscopic disease severity, and SMI can be used as a reliable indicator of disease activity status.https://www.frontiersin.org/articles/10.3389/fnut.2023.1251448/fullCrohn’s diseasebody compositiondisease behaviordisease activity statusmalnutrition |
| spellingShingle | Wuli Tang Wuli Tang Wuli Tang Wuli Tang Gang Xie Junlin Li Wei Tan Rongqi Yi Ling Yang Lingqin Zhang Jiaxing Deng Yue Zhang Kang Li Kang Li Kang Li Kang Li Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximab Frontiers in Nutrition Crohn’s disease body composition disease behavior disease activity status malnutrition |
| title | Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximab |
| title_full | Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximab |
| title_fullStr | Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximab |
| title_full_unstemmed | Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximab |
| title_short | Body composition parameters correlate with the endoscopic severity in Crohn’s disease patients treated with infliximab |
| title_sort | body composition parameters correlate with the endoscopic severity in crohn s disease patients treated with infliximab |
| topic | Crohn’s disease body composition disease behavior disease activity status malnutrition |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1251448/full |
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