Channelrhodopsin-2 Function is Modulated by Residual Hydrophobic Mismatch with the Surrounding Lipid Environment

Channelrhodopsin-2 Function is Modulated by Residual Hydrophobic Mismatch with the Surrounding Lipid Environment

Channelrhodopsin-2 (ChR2) is a light-gated ion channel that conducts cations of multiple valencies down the electrochemical gradient. This light-gated property has made ChR2 a popular tool in the field of optogenetics, allowing for the spatial and temporal control of excitable cells with light. A ce...

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Bibliographic Details
Main Authors:	Ryan Richards, Sayan Mondal, Harel Weinstein, Robert E. Dempski
Format:	Article
Language:	English
Published:	MDPI AG 2019-06-01
Series:	Applied Sciences
Subjects:	<i>Chlamydomonas reinhardtii</i> ion channel optogenetics electrophysiology molecular dynamics simulations membrane-protein interaction energy of membrane deformation CTMD method, residual hydrophobic mismatch
Online Access:	https://www.mdpi.com/2076-3417/9/13/2674

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