Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse

Increased Collagen I/Collagen III Ratio Is Associated with Hemorrhage in Brain Arteriovenous Malformations in Human and Mouse

<b>Background:</b> The increase in the collagen I (COL I)/COL III ratio enhances vessel wall stiffness and renders vessels less resistant to blood flow and pressure changes. Activated microglia enhance inflammation-induced fibrosis. <b>Hypotheses:</b> The COL I/COL III ratio...

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Bibliographic Details
Main Authors: Zahra Shabani, Joana Schuerger, Xiaonan Zhu, Chaoliang Tang, Li Ma, Alka Yadav, Rich Liang, Kelly Press, Shantel Weinsheimer, Annika Schmidt, Calvin Wang, Abinav Sekhar, Jeffrey Nelson, Helen Kim, Hua Su
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
brain arteriovenous malformation
collagen I
collagen III
microhemorrhage
depletion of microglia
gluycoprotein nonmetastatic B
Online Access:https://www.mdpi.com/2073-4409/13/1/92

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