Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female Rats
Background: <i>Costus spicatus</i> (Jacq.) Sw. is a medicinal species frequently prescribed for the treatment of cardiovascular diseases. This study aims to evaluate the effects of this species against the development of atherosclerosis. Methods: First, an anatomical study of the <i&g...
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MDPI AG
2021-03-01
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| Online Access: | https://www.mdpi.com/2075-1729/11/3/212 |
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| author | Bethânia Rosa Lorençone Lucas Pires Guarnier Rhanany Alan Calloi Palozi Paulo Vitor Moreira Romão Aline Aparecida Macedo Marques Lislaine Maria Klider Roosevelt Isaias Carvalho Souza Ariany Carvalho dos Santos Cleide Adriane Signor Tirloni Nadla Soares Cassemiro Denise Brentan Silva Jane Manfron Budel Arquimedes Gasparotto Junior |
| author_facet | Bethânia Rosa Lorençone Lucas Pires Guarnier Rhanany Alan Calloi Palozi Paulo Vitor Moreira Romão Aline Aparecida Macedo Marques Lislaine Maria Klider Roosevelt Isaias Carvalho Souza Ariany Carvalho dos Santos Cleide Adriane Signor Tirloni Nadla Soares Cassemiro Denise Brentan Silva Jane Manfron Budel Arquimedes Gasparotto Junior |
| author_sort | Bethânia Rosa Lorençone |
| collection | DOAJ |
| description | Background: <i>Costus spicatus</i> (Jacq.) Sw. is a medicinal species frequently prescribed for the treatment of cardiovascular diseases. This study aims to evaluate the effects of this species against the development of atherosclerosis. Methods: First, an anatomical study of the <i>C. spicatus</i> leaves was performed. Then, the extract (ESCS) was obtained and submitted to phytochemical analysis. Female rats were treated with a single dose of ESCS (2000 mg/kg) to assess acute toxicity. Other groups of female rats received an atherogenic diet for 60 days. After 30 days, the animals were treated orally with ESCS (30 and 300 mg/kg), rosuvastatin (5 mg/kg), or vehicle once daily for 30 days. Serum lipids oxidized low-density lipoprotein, soluble adhesion molecules, interleukins 1β and 6, and markers of renal and liver function were measured. Renal function, blood pressure, electrocardiography, and vascular reactivity were also evaluated. Arteries, heart, liver, and kidney were also collected to evaluate the tissue redox state and histopathological analysis. Results: Prolonged treatment with ESCS induces significant hypolipidemic and antioxidant effects, that prevent endothelial dysfunction and modulated the local inflammatory process, reducing the evolution of the atherosclerotic disease. Conclusions: This study provides a scientific basis for the popular use of <i>C. spicatus</i> for the treatment of atherosclerosis. |
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| language | English |
| last_indexed | 2024-03-10T13:26:40Z |
| publishDate | 2021-03-01 |
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| series | Life |
| spelling | doaj.art-f8a603a9c2b34977a5f77ad7d955d2d12023-11-21T09:37:45ZengMDPI AGLife2075-17292021-03-0111321210.3390/life11030212Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female RatsBethânia Rosa Lorençone0Lucas Pires Guarnier1Rhanany Alan Calloi Palozi2Paulo Vitor Moreira Romão3Aline Aparecida Macedo Marques4Lislaine Maria Klider5Roosevelt Isaias Carvalho Souza6Ariany Carvalho dos Santos7Cleide Adriane Signor Tirloni8Nadla Soares Cassemiro9Denise Brentan Silva10Jane Manfron Budel11Arquimedes Gasparotto Junior12Laboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilPostgraduate Program in Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa 84.030-900, PR, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilLaboratory of Natural Products and Mass Spectrometry (LaPNEM), Faculty of Pharmaceutical Sciences, Food and Nutrition (FACFAN), Federal University of Mato Grosso do Sul, Campo Grande 79.070-900, MS, BrazilLaboratory of Natural Products and Mass Spectrometry (LaPNEM), Faculty of Pharmaceutical Sciences, Food and Nutrition (FACFAN), Federal University of Mato Grosso do Sul, Campo Grande 79.070-900, MS, BrazilPostgraduate Program in Pharmaceutical Sciences, State University of Ponta Grossa, Ponta Grossa 84.030-900, PR, BrazilLaboratory of Cardiovascular Pharmacology (LaFaC), Faculty of Health Sciences, Federal University of Grande Dourados, Dourados 79.804-970, MS, BrazilBackground: <i>Costus spicatus</i> (Jacq.) Sw. is a medicinal species frequently prescribed for the treatment of cardiovascular diseases. This study aims to evaluate the effects of this species against the development of atherosclerosis. Methods: First, an anatomical study of the <i>C. spicatus</i> leaves was performed. Then, the extract (ESCS) was obtained and submitted to phytochemical analysis. Female rats were treated with a single dose of ESCS (2000 mg/kg) to assess acute toxicity. Other groups of female rats received an atherogenic diet for 60 days. After 30 days, the animals were treated orally with ESCS (30 and 300 mg/kg), rosuvastatin (5 mg/kg), or vehicle once daily for 30 days. Serum lipids oxidized low-density lipoprotein, soluble adhesion molecules, interleukins 1β and 6, and markers of renal and liver function were measured. Renal function, blood pressure, electrocardiography, and vascular reactivity were also evaluated. Arteries, heart, liver, and kidney were also collected to evaluate the tissue redox state and histopathological analysis. Results: Prolonged treatment with ESCS induces significant hypolipidemic and antioxidant effects, that prevent endothelial dysfunction and modulated the local inflammatory process, reducing the evolution of the atherosclerotic disease. Conclusions: This study provides a scientific basis for the popular use of <i>C. spicatus</i> for the treatment of atherosclerosis.https://www.mdpi.com/2075-1729/11/3/212antioxidantanti-inflammatoryCostaceaedyslipidemiaflavonoids |
| spellingShingle | Bethânia Rosa Lorençone Lucas Pires Guarnier Rhanany Alan Calloi Palozi Paulo Vitor Moreira Romão Aline Aparecida Macedo Marques Lislaine Maria Klider Roosevelt Isaias Carvalho Souza Ariany Carvalho dos Santos Cleide Adriane Signor Tirloni Nadla Soares Cassemiro Denise Brentan Silva Jane Manfron Budel Arquimedes Gasparotto Junior Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female Rats Life antioxidant anti-inflammatory Costaceae dyslipidemia flavonoids |
| title | Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female Rats |
| title_full | Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female Rats |
| title_fullStr | Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female Rats |
| title_full_unstemmed | Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female Rats |
| title_short | Atheroprotective Properties of <i>Costus spicatus</i> (Jacq.) Sw. in Female Rats |
| title_sort | atheroprotective properties of i costus spicatus i jacq sw in female rats |
| topic | antioxidant anti-inflammatory Costaceae dyslipidemia flavonoids |
| url | https://www.mdpi.com/2075-1729/11/3/212 |
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