Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution.
BACKGROUND:Nasopharyngeal carcinoma (NPC) is a race-specific malignancy. The nasal cavity is the main entry point for air pollutants or poisonous gases into the human body. However, the risk of NPC in populations exposed to air pollution remains unknown. METHODS:We combined data from the Taiwan Air...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6161893?pdf=render |
| _version_ | 1811262146249490432 |
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| author | Hueng-Chuen Fan Chiu-Ying Chen Yi-Chao Hsu Ruey-Hwang Chou Chieh-Lin Jerry Teng Chun-Hsiang Chiu Chung Y Hsu Chih-Hsin Muo Mei-Yin Chang Kuang-Hsi Chang |
| author_facet | Hueng-Chuen Fan Chiu-Ying Chen Yi-Chao Hsu Ruey-Hwang Chou Chieh-Lin Jerry Teng Chun-Hsiang Chiu Chung Y Hsu Chih-Hsin Muo Mei-Yin Chang Kuang-Hsi Chang |
| author_sort | Hueng-Chuen Fan |
| collection | DOAJ |
| description | BACKGROUND:Nasopharyngeal carcinoma (NPC) is a race-specific malignancy. The nasal cavity is the main entry point for air pollutants or poisonous gases into the human body. However, the risk of NPC in populations exposed to air pollution remains unknown. METHODS:We combined data from the Taiwan Air Quality Monitoring Database (TAQMD) and the Longitudinal Health Insurance Database (LHID) to assess the risk of NPC in a population exposed to air pollution. RESULTS:Multivariate analysis revealed positive trends for the association between the risk of NPC and exposure to air pollution. After adjusting for potential covariates, the risk of developing NPC increased with the increase in nitrogen dioxide (NO2) and fine particulate matter (PM2.5) exposure concentrations from 1.39 to 2.28 and 2.01 to 1.97, respectively, compared to the risks at the lowest concentration levels. CONCLUSIONS:We identified a significant risk of NPC in a population exposed to air pollution. However, this study had several limitations. Moreover, additional experimental and clinical studies on the associations between environmental factors and NPC risk are warranted. |
| first_indexed | 2024-04-12T19:19:58Z |
| format | Article |
| id | doaj.art-f8a7c7647e8c473eaf4e0a1fe5abe2ec |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T19:19:58Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f8a7c7647e8c473eaf4e0a1fe5abe2ec2022-12-22T03:19:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01139e020456810.1371/journal.pone.0204568Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution.Hueng-Chuen FanChiu-Ying ChenYi-Chao HsuRuey-Hwang ChouChieh-Lin Jerry TengChun-Hsiang ChiuChung Y HsuChih-Hsin MuoMei-Yin ChangKuang-Hsi ChangBACKGROUND:Nasopharyngeal carcinoma (NPC) is a race-specific malignancy. The nasal cavity is the main entry point for air pollutants or poisonous gases into the human body. However, the risk of NPC in populations exposed to air pollution remains unknown. METHODS:We combined data from the Taiwan Air Quality Monitoring Database (TAQMD) and the Longitudinal Health Insurance Database (LHID) to assess the risk of NPC in a population exposed to air pollution. RESULTS:Multivariate analysis revealed positive trends for the association between the risk of NPC and exposure to air pollution. After adjusting for potential covariates, the risk of developing NPC increased with the increase in nitrogen dioxide (NO2) and fine particulate matter (PM2.5) exposure concentrations from 1.39 to 2.28 and 2.01 to 1.97, respectively, compared to the risks at the lowest concentration levels. CONCLUSIONS:We identified a significant risk of NPC in a population exposed to air pollution. However, this study had several limitations. Moreover, additional experimental and clinical studies on the associations between environmental factors and NPC risk are warranted.http://europepmc.org/articles/PMC6161893?pdf=render |
| spellingShingle | Hueng-Chuen Fan Chiu-Ying Chen Yi-Chao Hsu Ruey-Hwang Chou Chieh-Lin Jerry Teng Chun-Hsiang Chiu Chung Y Hsu Chih-Hsin Muo Mei-Yin Chang Kuang-Hsi Chang Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. PLoS ONE |
| title | Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. |
| title_full | Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. |
| title_fullStr | Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. |
| title_full_unstemmed | Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. |
| title_short | Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. |
| title_sort | increased risk of incident nasopharyngeal carcinoma with exposure to air pollution |
| url | http://europepmc.org/articles/PMC6161893?pdf=render |
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