Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain Injury
Cardiac arrest (CA) remains the leading cause of coma, and early arousal recovery indicators are needed to allocate critical care resources properly. High-frequency oscillations (HFOs) of somatosensory evoked potentials (SSEPs) have been shown to indicate responsive wakefulness days following CA. No...
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MDPI AG
2022-12-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/13/1/2 |
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| author | Ze Ou Yu Guo Payam Gharibani Ariel Slepyan Denis Routkevitch Anastasios Bezerianos Romergryko G. Geocadin Nitish V. Thakor |
| author_facet | Ze Ou Yu Guo Payam Gharibani Ariel Slepyan Denis Routkevitch Anastasios Bezerianos Romergryko G. Geocadin Nitish V. Thakor |
| author_sort | Ze Ou |
| collection | DOAJ |
| description | Cardiac arrest (CA) remains the leading cause of coma, and early arousal recovery indicators are needed to allocate critical care resources properly. High-frequency oscillations (HFOs) of somatosensory evoked potentials (SSEPs) have been shown to indicate responsive wakefulness days following CA. Nonetheless, their potential in the acute recovery phase, where the injury is reversible, has not been tested. We hypothesize that time-frequency (TF) analysis of HFOs can determine arousal recovery in the acute recovery phase. To test our hypothesis, eleven adult male Wistar rats were subjected to asphyxial CA (five with 3-min mild and six with 7-min moderate to severe CA) and SSEPs were recorded for 60 min post-resuscitation. Arousal level was quantified by the neurological deficit scale (NDS) at 4 h. Our results demonstrated that continuous wavelet transform (CWT) of SSEPs localizes HFOs in the TF domain under baseline conditions. The energy dispersed immediately after injury and gradually recovered. We proposed a novel TF-domain measure of HFO: the total power in the normal time-frequency space (NTFS) of HFO. We found that the NTFS power significantly separated the favorable and unfavorable outcome groups. We conclude that the NTFS power of HFOs provides earlier and objective determination of arousal recovery after CA. |
| first_indexed | 2024-03-09T13:24:52Z |
| format | Article |
| id | doaj.art-f8a83570098545e184d3a3bbccfc3d8c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T13:24:52Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-f8a83570098545e184d3a3bbccfc3d8c2023-11-30T21:26:12ZengMDPI AGBrain Sciences2076-34252022-12-01131210.3390/brainsci13010002Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain InjuryZe Ou0Yu Guo1Payam Gharibani2Ariel Slepyan3Denis Routkevitch4Anastasios Bezerianos5Romergryko G. Geocadin6Nitish V. Thakor7Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartments of Neurology, Division of Neuroimmunology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USADepartments of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USADepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAInformation Technologies Institute (ITI), Center for Research and Technology Hellas (CERTH), 57001 Thessaloniki, GreeceDepartments of Neurology, Anesthesiology, Critical Care Medicine and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USACardiac arrest (CA) remains the leading cause of coma, and early arousal recovery indicators are needed to allocate critical care resources properly. High-frequency oscillations (HFOs) of somatosensory evoked potentials (SSEPs) have been shown to indicate responsive wakefulness days following CA. Nonetheless, their potential in the acute recovery phase, where the injury is reversible, has not been tested. We hypothesize that time-frequency (TF) analysis of HFOs can determine arousal recovery in the acute recovery phase. To test our hypothesis, eleven adult male Wistar rats were subjected to asphyxial CA (five with 3-min mild and six with 7-min moderate to severe CA) and SSEPs were recorded for 60 min post-resuscitation. Arousal level was quantified by the neurological deficit scale (NDS) at 4 h. Our results demonstrated that continuous wavelet transform (CWT) of SSEPs localizes HFOs in the TF domain under baseline conditions. The energy dispersed immediately after injury and gradually recovered. We proposed a novel TF-domain measure of HFO: the total power in the normal time-frequency space (NTFS) of HFO. We found that the NTFS power significantly separated the favorable and unfavorable outcome groups. We conclude that the NTFS power of HFOs provides earlier and objective determination of arousal recovery after CA.https://www.mdpi.com/2076-3425/13/1/2somatosensory evoked potentialshigh-frequency oscillationscardiac arrestcontinuous wavelet transformhypoxic-ischemic injury |
| spellingShingle | Ze Ou Yu Guo Payam Gharibani Ariel Slepyan Denis Routkevitch Anastasios Bezerianos Romergryko G. Geocadin Nitish V. Thakor Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain Injury Brain Sciences somatosensory evoked potentials high-frequency oscillations cardiac arrest continuous wavelet transform hypoxic-ischemic injury |
| title | Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain Injury |
| title_full | Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain Injury |
| title_fullStr | Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain Injury |
| title_full_unstemmed | Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain Injury |
| title_short | Time-Frequency Analysis of Somatosensory Evoked High-Frequency (600 Hz) Oscillations as an Early Indicator of Arousal Recovery after Hypoxic-Ischemic Brain Injury |
| title_sort | time frequency analysis of somatosensory evoked high frequency 600 hz oscillations as an early indicator of arousal recovery after hypoxic ischemic brain injury |
| topic | somatosensory evoked potentials high-frequency oscillations cardiac arrest continuous wavelet transform hypoxic-ischemic injury |
| url | https://www.mdpi.com/2076-3425/13/1/2 |
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