S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics
Glutamate acting on AMPA-type ionotropic glutamate receptor (AMPAR) mediates the majority of fast excitatory synaptic transmission in the mammalian central nervous system. Dynamic regulation of AMPAR by post-translational modifications is one of the key elements that allow the nervous system to adap...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383514001233 |
| _version_ | 1811298516389068800 |
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| author | Jun Han Pengfei Wu Fang Wang Jianguo Chen |
| author_facet | Jun Han Pengfei Wu Fang Wang Jianguo Chen |
| author_sort | Jun Han |
| collection | DOAJ |
| description | Glutamate acting on AMPA-type ionotropic glutamate receptor (AMPAR) mediates the majority of fast excitatory synaptic transmission in the mammalian central nervous system. Dynamic regulation of AMPAR by post-translational modifications is one of the key elements that allow the nervous system to adapt to environment stimulations. S-palmitoylation, an important lipid modification by post-translational addition of a long-chain fatty acid to a cysteine residue, regulates AMPA receptor trafficking, which dynamically affects multiple fundamental brain functions, such as learning and memory. In vivo, S-palmitoylation is controlled by palmitoyl acyl transferases and palmitoyl thioesterases. In this review, we highlight advances in the mechanisms for dynamic AMPA receptors palmitoylation, and discuss how palmitoylation affects AMPA receptors function at synapses in recent years. Pharmacological regulation of S-palmitoylation may serve as a novel therapeutic strategy for neurobiological diseases. |
| first_indexed | 2024-04-13T06:21:23Z |
| format | Article |
| id | doaj.art-f8aa92ed9ff24b6fbd87a17ab6bf0b3f |
| institution | Directory Open Access Journal |
| issn | 2211-3835 2211-3843 |
| language | English |
| last_indexed | 2024-04-13T06:21:23Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-f8aa92ed9ff24b6fbd87a17ab6bf0b3f2022-12-22T02:58:39ZengElsevierActa Pharmaceutica Sinica B2211-38352211-38432015-01-01511710.1016/j.apsb.2014.12.002S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeuticsJun Han0Pengfei Wu1Fang Wang2Jianguo Chen3Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaGlutamate acting on AMPA-type ionotropic glutamate receptor (AMPAR) mediates the majority of fast excitatory synaptic transmission in the mammalian central nervous system. Dynamic regulation of AMPAR by post-translational modifications is one of the key elements that allow the nervous system to adapt to environment stimulations. S-palmitoylation, an important lipid modification by post-translational addition of a long-chain fatty acid to a cysteine residue, regulates AMPA receptor trafficking, which dynamically affects multiple fundamental brain functions, such as learning and memory. In vivo, S-palmitoylation is controlled by palmitoyl acyl transferases and palmitoyl thioesterases. In this review, we highlight advances in the mechanisms for dynamic AMPA receptors palmitoylation, and discuss how palmitoylation affects AMPA receptors function at synapses in recent years. Pharmacological regulation of S-palmitoylation may serve as a novel therapeutic strategy for neurobiological diseases.http://www.sciencedirect.com/science/article/pii/S2211383514001233PalmitoylationAMPA receptorsTraffickingDHHC |
| spellingShingle | Jun Han Pengfei Wu Fang Wang Jianguo Chen S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics Acta Pharmaceutica Sinica B Palmitoylation AMPA receptors Trafficking DHHC |
| title | S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics |
| title_full | S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics |
| title_fullStr | S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics |
| title_full_unstemmed | S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics |
| title_short | S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics |
| title_sort | s palmitoylation regulates ampa receptors trafficking and function a novel insight into synaptic regulation and therapeutics |
| topic | Palmitoylation AMPA receptors Trafficking DHHC |
| url | http://www.sciencedirect.com/science/article/pii/S2211383514001233 |
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