Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients
IntroductionKidney transplant recipients showed a weak humoral response to the mRNA COVID-19 vaccine despite receiving three cumulative doses of the vaccine. New approaches are still needed to raise protective immunity conferred by the vaccine administration within this group of high-risk patients....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1099079/full |
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| author | Ángel Bulnes-Ramos María Mar Pozo-Balado Israel Olivas-Martínez Vanesa Garrido-Rodríguez Gabriel Bernal-Blanco Alejandro Suárez-Benjumea Ana Isabel Álvarez-Ríos Carmen Lozano Carmen González-Corvillo Marta Suñer-Poblet Francisco Manuel González-Roncero Berta Sánchez Isabel Maldonado-Calzado José Manuel Lara-Ruiz María Francisca Gonzalez-Escribano Yolanda María Pacheco |
| author_facet | Ángel Bulnes-Ramos María Mar Pozo-Balado Israel Olivas-Martínez Vanesa Garrido-Rodríguez Gabriel Bernal-Blanco Alejandro Suárez-Benjumea Ana Isabel Álvarez-Ríos Carmen Lozano Carmen González-Corvillo Marta Suñer-Poblet Francisco Manuel González-Roncero Berta Sánchez Isabel Maldonado-Calzado José Manuel Lara-Ruiz María Francisca Gonzalez-Escribano Yolanda María Pacheco |
| author_sort | Ángel Bulnes-Ramos |
| collection | DOAJ |
| description | IntroductionKidney transplant recipients showed a weak humoral response to the mRNA COVID-19 vaccine despite receiving three cumulative doses of the vaccine. New approaches are still needed to raise protective immunity conferred by the vaccine administration within this group of high-risk patients. MethodsTo analyze the humoral response and identify any predictive factors within these patients, we designed a prospective monocentric longitudinal study of Kidney transplant recipients (KTR) who received three doses of mRNA-1273 COVID-19 vaccine. Specific antibody levels were measured by chemiluminescence. Parameters related to clinical status such as kidney function, immunosuppressive therapy, inflammatory status and thymic function were analyzed as potential predictors of the humoral response. ResultsSeventy-four KTR and sixteen healthy controls were included. One month after the administration of the third dose of the COVID-19 vaccine, 64.8% of KTR showed a positive humoral response. As predictive factors of seroconversion and specific antibody titer, we found that immunosuppressive therapy, worse kidney function, higher inflammatory status and age were related to a lower response in KTR while immune cell counts, thymosin-a1 plasma concentration and thymic output were related to a higher humoral response. Furthermore, baseline thymosin-a1 concentration was independently associated with the seroconversion after three vaccine doses. DiscussionIn addition to the immunosuppression therapy, condition of kidney function and age before vaccination, specific immune factors could also be relevant in light of optimization of the COVID-19 vaccination protocol in KTR. Therefore, thymosin-a1, an immunomodulatory hormone, deserves further research as a potential adjuvant for the next vaccine boosters. |
| first_indexed | 2024-04-10T10:01:50Z |
| format | Article |
| id | doaj.art-f8ad1ac0972e44af8a64fccc484a3f33 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T10:01:50Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f8ad1ac0972e44af8a64fccc484a3f332023-02-16T07:32:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.10990791099079Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipientsÁngel Bulnes-Ramos0María Mar Pozo-Balado1Israel Olivas-Martínez2Vanesa Garrido-Rodríguez3Gabriel Bernal-Blanco4Alejandro Suárez-Benjumea5Ana Isabel Álvarez-Ríos6Carmen Lozano7Carmen González-Corvillo8Marta Suñer-Poblet9Francisco Manuel González-Roncero10Berta Sánchez11Isabel Maldonado-Calzado12José Manuel Lara-Ruiz13María Francisca Gonzalez-Escribano14Yolanda María Pacheco15Immunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainNephrology Service, University Hospital Virgen del Rocío, Seville, SpainNephrology Service, University Hospital Virgen del Rocío, Seville, SpainBiochemistry Service, University Hospital Virgen del Rocío, Seville, SpainMicrobiology Service, University Hospital Virgen del Rocío, Seville, SpainNephrology Service, University Hospital Virgen del Rocío, Seville, SpainNephrology Service, University Hospital Virgen del Rocío, Seville, SpainNephrology Service, University Hospital Virgen del Rocío, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainImmunology Service, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital (HUVR)/CSIC/University of Seville, Seville, SpainIntroductionKidney transplant recipients showed a weak humoral response to the mRNA COVID-19 vaccine despite receiving three cumulative doses of the vaccine. New approaches are still needed to raise protective immunity conferred by the vaccine administration within this group of high-risk patients. MethodsTo analyze the humoral response and identify any predictive factors within these patients, we designed a prospective monocentric longitudinal study of Kidney transplant recipients (KTR) who received three doses of mRNA-1273 COVID-19 vaccine. Specific antibody levels were measured by chemiluminescence. Parameters related to clinical status such as kidney function, immunosuppressive therapy, inflammatory status and thymic function were analyzed as potential predictors of the humoral response. ResultsSeventy-four KTR and sixteen healthy controls were included. One month after the administration of the third dose of the COVID-19 vaccine, 64.8% of KTR showed a positive humoral response. As predictive factors of seroconversion and specific antibody titer, we found that immunosuppressive therapy, worse kidney function, higher inflammatory status and age were related to a lower response in KTR while immune cell counts, thymosin-a1 plasma concentration and thymic output were related to a higher humoral response. Furthermore, baseline thymosin-a1 concentration was independently associated with the seroconversion after three vaccine doses. DiscussionIn addition to the immunosuppression therapy, condition of kidney function and age before vaccination, specific immune factors could also be relevant in light of optimization of the COVID-19 vaccination protocol in KTR. Therefore, thymosin-a1, an immunomodulatory hormone, deserves further research as a potential adjuvant for the next vaccine boosters.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1099079/fullCOVID-19kidney transplantmRNA vaccinerelative telomere lengththymic functionthymosin-α1 |
| spellingShingle | Ángel Bulnes-Ramos María Mar Pozo-Balado Israel Olivas-Martínez Vanesa Garrido-Rodríguez Gabriel Bernal-Blanco Alejandro Suárez-Benjumea Ana Isabel Álvarez-Ríos Carmen Lozano Carmen González-Corvillo Marta Suñer-Poblet Francisco Manuel González-Roncero Berta Sánchez Isabel Maldonado-Calzado José Manuel Lara-Ruiz María Francisca Gonzalez-Escribano Yolanda María Pacheco Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients Frontiers in Immunology COVID-19 kidney transplant mRNA vaccine relative telomere length thymic function thymosin-α1 |
| title | Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients |
| title_full | Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients |
| title_fullStr | Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients |
| title_full_unstemmed | Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients |
| title_short | Factors associated with the humoral response after three doses of COVID-19 vaccination in kidney transplant recipients |
| title_sort | factors associated with the humoral response after three doses of covid 19 vaccination in kidney transplant recipients |
| topic | COVID-19 kidney transplant mRNA vaccine relative telomere length thymic function thymosin-α1 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1099079/full |
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