Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial
Abstract Background Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effectiveness of oral clonidine and gabapentin on peripheral neuropathy in dia...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-10-01
|
| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01486-0 |
| _version_ | 1827634008224169984 |
|---|---|
| author | Sajad Hassanzadeh Soraya Bagheri Seyed Majid Ahmadi Seyed Ahmadreza Ahmadi Isaac Moradishibany Hosein Dolatkhah Sajjad Reisi |
| author_facet | Sajad Hassanzadeh Soraya Bagheri Seyed Majid Ahmadi Seyed Ahmadreza Ahmadi Isaac Moradishibany Hosein Dolatkhah Sajjad Reisi |
| author_sort | Sajad Hassanzadeh |
| collection | DOAJ |
| description | Abstract Background Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients. Methods This 12-week, randomized, and parallel-group trial was conducted to compare the efficacy of oral clonidine and gabapentin with gabapentin alone in diabetic patients in southwest Iran during the first half of 2021. Thirty patients with type 2 diabetes with peripheral neuropathy as assessed by a visual analog scale (VAS) and divided into two groups of 15 patients, treated for up to three months. The data were analyzed using SPSS-21 software. In order to report the results, descriptive indices, independent t-test, one-way analysis of covariance (ANCOVA) and analysis of variance with repeated measures were used. Results The mean and standard deviation of the age of the participants in the clonidine + gabapentin group was equal to 50.20 ± 7.44, and in the gabapentin group was equal to 50.47 ± 7.57 (t = 0.10, P-value = 0.923). This research showed a significant difference between the clonidine + gabapentin group and with gabapentin group in terms of neuropathic pain and the severity of neuropathic pain (P < 0.001). Conclusions According to this research results, clonidine + gabapentin can reduce neuropathic pain and the severity of neuropathic pain in diabetic patients. Therefore, it is recommended that healthcare professionals with diabetes expertise prescribe these medications to reduce neuropathic pain and its severity. Trial registration This study was registered in the Iranian Clinical Trials System with the ID (IRCT20211106052983N1) on 14/01/2022. |
| first_indexed | 2024-03-09T15:07:27Z |
| format | Article |
| id | doaj.art-f8ae86246e344e8e8f0c08f408578fce |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-09T15:07:27Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-f8ae86246e344e8e8f0c08f408578fce2023-11-26T13:34:48ZengBMCBMC Endocrine Disorders1472-68232023-10-0123111010.1186/s12902-023-01486-0Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trialSajad Hassanzadeh0Soraya Bagheri1Seyed Majid Ahmadi2Seyed Ahmadreza Ahmadi3Isaac Moradishibany4Hosein Dolatkhah5Sajjad Reisi6Department of Internal Medicine, School of Medicine, Yasuj University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Yasuj University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Yasuj University of Medical SciencesSchool of Medicine, Jundishahpour University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Yasuj University of Medical SciencesDepartment of Internal Medicine, School of Medicine, Yasuj University of Medical SciencesGenetic and Environmental Adventures Research Center, School of Abarkouh Paramedicine, Shahid Sadoughi University of Medical SciencesAbstract Background Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine the effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients. Methods This 12-week, randomized, and parallel-group trial was conducted to compare the efficacy of oral clonidine and gabapentin with gabapentin alone in diabetic patients in southwest Iran during the first half of 2021. Thirty patients with type 2 diabetes with peripheral neuropathy as assessed by a visual analog scale (VAS) and divided into two groups of 15 patients, treated for up to three months. The data were analyzed using SPSS-21 software. In order to report the results, descriptive indices, independent t-test, one-way analysis of covariance (ANCOVA) and analysis of variance with repeated measures were used. Results The mean and standard deviation of the age of the participants in the clonidine + gabapentin group was equal to 50.20 ± 7.44, and in the gabapentin group was equal to 50.47 ± 7.57 (t = 0.10, P-value = 0.923). This research showed a significant difference between the clonidine + gabapentin group and with gabapentin group in terms of neuropathic pain and the severity of neuropathic pain (P < 0.001). Conclusions According to this research results, clonidine + gabapentin can reduce neuropathic pain and the severity of neuropathic pain in diabetic patients. Therefore, it is recommended that healthcare professionals with diabetes expertise prescribe these medications to reduce neuropathic pain and its severity. Trial registration This study was registered in the Iranian Clinical Trials System with the ID (IRCT20211106052983N1) on 14/01/2022.https://doi.org/10.1186/s12902-023-01486-0ClonidineGabapentinPeripheral neuropathyDiabetesNeuropathic painSeverity of neuropathic pain |
| spellingShingle | Sajad Hassanzadeh Soraya Bagheri Seyed Majid Ahmadi Seyed Ahmadreza Ahmadi Isaac Moradishibany Hosein Dolatkhah Sajjad Reisi Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial BMC Endocrine Disorders Clonidine Gabapentin Peripheral neuropathy Diabetes Neuropathic pain Severity of neuropathic pain |
| title | Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial |
| title_full | Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial |
| title_fullStr | Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial |
| title_full_unstemmed | Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial |
| title_short | Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial |
| title_sort | effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern iran a randomized clinical trial |
| topic | Clonidine Gabapentin Peripheral neuropathy Diabetes Neuropathic pain Severity of neuropathic pain |
| url | https://doi.org/10.1186/s12902-023-01486-0 |
| work_keys_str_mv | AT sajadhassanzadeh effectivenessoforalclonidineandgabapentinonperipheralneuropathyindiabeticpatientsinsouthwesterniranarandomizedclinicaltrial AT sorayabagheri effectivenessoforalclonidineandgabapentinonperipheralneuropathyindiabeticpatientsinsouthwesterniranarandomizedclinicaltrial AT seyedmajidahmadi effectivenessoforalclonidineandgabapentinonperipheralneuropathyindiabeticpatientsinsouthwesterniranarandomizedclinicaltrial AT seyedahmadrezaahmadi effectivenessoforalclonidineandgabapentinonperipheralneuropathyindiabeticpatientsinsouthwesterniranarandomizedclinicaltrial AT isaacmoradishibany effectivenessoforalclonidineandgabapentinonperipheralneuropathyindiabeticpatientsinsouthwesterniranarandomizedclinicaltrial AT hoseindolatkhah effectivenessoforalclonidineandgabapentinonperipheralneuropathyindiabeticpatientsinsouthwesterniranarandomizedclinicaltrial AT sajjadreisi effectivenessoforalclonidineandgabapentinonperipheralneuropathyindiabeticpatientsinsouthwesterniranarandomizedclinicaltrial |