Crosstalk between Sensory Neurons and Local Immunity during Peripheral Inflammation
Sensory neurons, also known as afferent neurons, perceive noxious stimuli from internal as well as external environments through nociceptive receptors and then transmit these signals to the central nervous system. Similarly, the innate immune system also recognizes external and internal danger signa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-10-01
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| Series: | Stress and Brain |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/SAB.2022.9060001 |
| _version_ | 1797384846663745536 |
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| author | Muge Qile Shufang He |
| author_facet | Muge Qile Shufang He |
| author_sort | Muge Qile |
| collection | DOAJ |
| description | Sensory neurons, also known as afferent neurons, perceive noxious stimuli from internal as well as external environments through nociceptive receptors and then transmit these signals to the central nervous system. Similarly, the innate immune system also recognizes external and internal danger signals from invading microbes or tissue injuries. The immune system and sensory neurons share mechanisms to respond to pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through pattern recognition receptors. Recent studies have identified an inseparable bidirectional connection between sensory neurons and the immune system that is important for maintaining tissue homeostasis and regulating inflammatory states, as well as affecting the progression of inflammatory diseases. This review summarizes the recent findings on the crosstalk between sensory neurons and local immunity in peripheral tissues, including the skin, respiratory system, gastrointestinal tract, cornea, and joints. Understanding the mechanisms of this interaction can help in the development of therapeutic strategies to treat peripheral inflammatory diseases. |
| first_indexed | 2024-03-08T21:45:33Z |
| format | Article |
| id | doaj.art-f8af3ba324664fce8f8d21672727ebd1 |
| institution | Directory Open Access Journal |
| issn | 2709-1325 2709-0388 |
| language | English |
| last_indexed | 2024-03-08T21:45:33Z |
| publishDate | 2023-10-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Stress and Brain |
| spelling | doaj.art-f8af3ba324664fce8f8d21672727ebd12023-12-20T09:52:42ZengTsinghua University PressStress and Brain2709-13252709-03882023-10-0132697910.26599/SAB.2022.9060001Crosstalk between Sensory Neurons and Local Immunity during Peripheral InflammationMuge Qile0Shufang He1Department of Anesthesiology and Perioperative Medicine, the Second Affiliated Hospital of Anhui Medical University; Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, ChinaDepartment of Anesthesiology and Perioperative Medicine, the Second Affiliated Hospital of Anhui Medical University; Key Laboratory of Anesthesiology and Perioperative Medicine of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, ChinaSensory neurons, also known as afferent neurons, perceive noxious stimuli from internal as well as external environments through nociceptive receptors and then transmit these signals to the central nervous system. Similarly, the innate immune system also recognizes external and internal danger signals from invading microbes or tissue injuries. The immune system and sensory neurons share mechanisms to respond to pathogen/damage-associated molecular patterns (PAMPs/DAMPs) through pattern recognition receptors. Recent studies have identified an inseparable bidirectional connection between sensory neurons and the immune system that is important for maintaining tissue homeostasis and regulating inflammatory states, as well as affecting the progression of inflammatory diseases. This review summarizes the recent findings on the crosstalk between sensory neurons and local immunity in peripheral tissues, including the skin, respiratory system, gastrointestinal tract, cornea, and joints. Understanding the mechanisms of this interaction can help in the development of therapeutic strategies to treat peripheral inflammatory diseases.https://www.sciopen.com/article/10.26599/SAB.2022.9060001sensory neuronslocal immunityperipheral inflammationneuropeptidescytokines |
| spellingShingle | Muge Qile Shufang He Crosstalk between Sensory Neurons and Local Immunity during Peripheral Inflammation Stress and Brain sensory neurons local immunity peripheral inflammation neuropeptides cytokines |
| title | Crosstalk between Sensory Neurons and Local Immunity during Peripheral Inflammation |
| title_full | Crosstalk between Sensory Neurons and Local Immunity during Peripheral Inflammation |
| title_fullStr | Crosstalk between Sensory Neurons and Local Immunity during Peripheral Inflammation |
| title_full_unstemmed | Crosstalk between Sensory Neurons and Local Immunity during Peripheral Inflammation |
| title_short | Crosstalk between Sensory Neurons and Local Immunity during Peripheral Inflammation |
| title_sort | crosstalk between sensory neurons and local immunity during peripheral inflammation |
| topic | sensory neurons local immunity peripheral inflammation neuropeptides cytokines |
| url | https://www.sciopen.com/article/10.26599/SAB.2022.9060001 |
| work_keys_str_mv | AT mugeqile crosstalkbetweensensoryneuronsandlocalimmunityduringperipheralinflammation AT shufanghe crosstalkbetweensensoryneuronsandlocalimmunityduringperipheralinflammation |