Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years
Cutaneous candidiasis is one of the most prevalent mycotic infections caused by Candida species. The severity of infection mounts faster when the species shows antifungal resistance. In the current retrospective study, we aimed to analyze the occurrence, causes of cutaneous candidiasis, and antifung...
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2022.981181/full |
| _version_ | 1811315660951650304 |
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| author | Hazrat Bilal Bing Hou Muhammad Shafiq Xinyu Chen Muhammad Akbar Shahid Yuebin Zeng |
| author_facet | Hazrat Bilal Bing Hou Muhammad Shafiq Xinyu Chen Muhammad Akbar Shahid Yuebin Zeng |
| author_sort | Hazrat Bilal |
| collection | DOAJ |
| description | Cutaneous candidiasis is one of the most prevalent mycotic infections caused by Candida species. The severity of infection mounts faster when the species shows antifungal resistance. In the current retrospective study, we aimed to analyze the occurrence, causes of cutaneous candidiasis, and antifungal susceptibility pattern of Candida isolates from Skin and Venereal Diseases Prevention and Control Hospital of Shantou, located in eastern Guangdong, China. The laboratory data of all patients (n = 3,113) suffering from various skin and venereal infections during January 2012 to December 2021 was analyzed through Excel and GraphPad prism. Our analysis indicate that cutaneous candidiasis was 22.29% (n = 694), of which 78.53% (n = 554) of patients were males and 21.47% (n = 149) of patients were females. The median age of patients with cutaneous candidiasis was 38-year [interquartile range (30–48)]. Most cases occurred in the adult age group (19–50 years). Regarding the species type, the Candida albicans were prominently detected (n = 664, 95.68%), while non-C. albicans were found only in 30 (4.32%) patients, which were C. glabrata (n = 18), C. krusei (n = 8), C. tropicalis (n = 3), and C. parapsilosis (n = 1). The C. albicans susceptibility rate for terbinafine, miconazole, voriconazole, itraconazole, fluconazole, ketoconazole, nystatin, 5-flucytosine and amphotericin B were 10.83, 29.32, 59.39, 78.53, 85.28, 87.75, 99.59, 99.41, and 100%, respectively. Finally, all C. glabrata isolates were found susceptible to all tested azole drugs with exception to miconazole against which 8.33% of isolates showed resistance. The findings of this study will help healthcare officials to establish better antifungal stewardship in the region. |
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| language | English |
| last_indexed | 2024-04-13T11:34:42Z |
| publishDate | 2022-08-01 |
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| series | Frontiers in Microbiology |
| spelling | doaj.art-f8b06e442d20481ea416ad83c61ac8402022-12-22T02:48:28ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2022-08-011310.3389/fmicb.2022.981181981181Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 yearsHazrat Bilal0Bing Hou1Muhammad Shafiq2Xinyu Chen3Muhammad Akbar Shahid4Yuebin Zeng5Department of Dermatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, ChinaSkin and Venereal Diseases Prevention and Control Hospital of Shantou City, Shantou, Guangdong, ChinaDepartment of Cell Biology and Genetics, Shantou University Medical College, Shantou, ChinaDepartment of Dermatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, ChinaDepartment of Pathobiology, Faculty of Veterinary Sciences, Bahauddin Zakariya University, Multan, PakistanDepartment of Dermatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, ChinaCutaneous candidiasis is one of the most prevalent mycotic infections caused by Candida species. The severity of infection mounts faster when the species shows antifungal resistance. In the current retrospective study, we aimed to analyze the occurrence, causes of cutaneous candidiasis, and antifungal susceptibility pattern of Candida isolates from Skin and Venereal Diseases Prevention and Control Hospital of Shantou, located in eastern Guangdong, China. The laboratory data of all patients (n = 3,113) suffering from various skin and venereal infections during January 2012 to December 2021 was analyzed through Excel and GraphPad prism. Our analysis indicate that cutaneous candidiasis was 22.29% (n = 694), of which 78.53% (n = 554) of patients were males and 21.47% (n = 149) of patients were females. The median age of patients with cutaneous candidiasis was 38-year [interquartile range (30–48)]. Most cases occurred in the adult age group (19–50 years). Regarding the species type, the Candida albicans were prominently detected (n = 664, 95.68%), while non-C. albicans were found only in 30 (4.32%) patients, which were C. glabrata (n = 18), C. krusei (n = 8), C. tropicalis (n = 3), and C. parapsilosis (n = 1). The C. albicans susceptibility rate for terbinafine, miconazole, voriconazole, itraconazole, fluconazole, ketoconazole, nystatin, 5-flucytosine and amphotericin B were 10.83, 29.32, 59.39, 78.53, 85.28, 87.75, 99.59, 99.41, and 100%, respectively. Finally, all C. glabrata isolates were found susceptible to all tested azole drugs with exception to miconazole against which 8.33% of isolates showed resistance. The findings of this study will help healthcare officials to establish better antifungal stewardship in the region.https://www.frontiersin.org/articles/10.3389/fmicb.2022.981181/fullcutaneous candidiasisantifungal resistanceC. albicansretrospective studyChina |
| spellingShingle | Hazrat Bilal Bing Hou Muhammad Shafiq Xinyu Chen Muhammad Akbar Shahid Yuebin Zeng Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years Frontiers in Microbiology cutaneous candidiasis antifungal resistance C. albicans retrospective study China |
| title | Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years |
| title_full | Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years |
| title_fullStr | Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years |
| title_full_unstemmed | Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years |
| title_short | Antifungal susceptibility pattern of Candida isolated from cutaneous candidiasis patients in eastern Guangdong region: A retrospective study of the past 10 years |
| title_sort | antifungal susceptibility pattern of candida isolated from cutaneous candidiasis patients in eastern guangdong region a retrospective study of the past 10 years |
| topic | cutaneous candidiasis antifungal resistance C. albicans retrospective study China |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2022.981181/full |
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