Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms
Rabies is a vaccine-preventable fatal disease in man and most mammals. Although rabies is recorded in 150 territories and is responsible for at least 60,000 human deaths every year worldwide, it is a neglected tropical problem. Most of the rabies free countries are considered to be fragile free as t...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-04-01
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| Series: | International Journal of Veterinary Science and Medicine |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2314459918300632 |
| _version_ | 1819267450734116864 |
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| author | A El-Sayed |
| author_facet | A El-Sayed |
| author_sort | A El-Sayed |
| collection | DOAJ |
| description | Rabies is a vaccine-preventable fatal disease in man and most mammals. Although rabies is recorded in 150 territories and is responsible for at least 60,000 human deaths every year worldwide, it is a neglected tropical problem. Most of the rabies free countries are considered to be fragile free as the disease may re-emerge easily through wild mammals. For the performance of effective rabies eradication programs, a complex set of strategies and activities is required. At the time, a joint project of WHO–OIE–FAO which was announced in 2015, plans to control animal–human–ecosystems rabies interface. For effective rabies control, prophylactic policies must be applied. These include various educational outreaches for farmers and people living in endemic areas, enforced legislation for responsible dog ownership, control programs for the free-ranging stray dog and cat populations, field large-scale vaccination campaigns, and the development of new vaccine delivery strategies for both humans and animals. The present work presents the advances in the development of new safe, effective and economic vaccines for domestic dogs, and oral vaccines for the control of the disease in wild animals. It presents also some therapeutic protocols used for the treatment of patients. Keywords: Bat lyssavirus, Biting, Rabies, SAG1, Treatment, Vaccine |
| first_indexed | 2024-12-23T21:17:22Z |
| format | Article |
| id | doaj.art-f8b3f09e13514a99b4178b4d37425e6f |
| institution | Directory Open Access Journal |
| issn | 2314-4599 |
| language | English |
| last_indexed | 2024-12-23T21:17:22Z |
| publishDate | 2018-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Veterinary Science and Medicine |
| spelling | doaj.art-f8b3f09e13514a99b4178b4d37425e6f2022-12-21T17:30:52ZengTaylor & Francis GroupInternational Journal of Veterinary Science and Medicine2314-45992018-04-0161815Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanismsA El-Sayed0Address: Faculty of Veterinary Medicine, Giza Square, 11451 Giza, Egypt.; Faculty of Veterinary Medicine, Department of Medicine and Infectious Diseases, Cairo University, Giza, EgyptRabies is a vaccine-preventable fatal disease in man and most mammals. Although rabies is recorded in 150 territories and is responsible for at least 60,000 human deaths every year worldwide, it is a neglected tropical problem. Most of the rabies free countries are considered to be fragile free as the disease may re-emerge easily through wild mammals. For the performance of effective rabies eradication programs, a complex set of strategies and activities is required. At the time, a joint project of WHO–OIE–FAO which was announced in 2015, plans to control animal–human–ecosystems rabies interface. For effective rabies control, prophylactic policies must be applied. These include various educational outreaches for farmers and people living in endemic areas, enforced legislation for responsible dog ownership, control programs for the free-ranging stray dog and cat populations, field large-scale vaccination campaigns, and the development of new vaccine delivery strategies for both humans and animals. The present work presents the advances in the development of new safe, effective and economic vaccines for domestic dogs, and oral vaccines for the control of the disease in wild animals. It presents also some therapeutic protocols used for the treatment of patients. Keywords: Bat lyssavirus, Biting, Rabies, SAG1, Treatment, Vaccinehttp://www.sciencedirect.com/science/article/pii/S2314459918300632 |
| spellingShingle | A El-Sayed Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms International Journal of Veterinary Science and Medicine |
| title | Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms |
| title_full | Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms |
| title_fullStr | Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms |
| title_full_unstemmed | Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms |
| title_short | Advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms |
| title_sort | advances in rabies prophylaxis and treatment with emphasis on immunoresponse mechanisms |
| url | http://www.sciencedirect.com/science/article/pii/S2314459918300632 |
| work_keys_str_mv | AT aelsayed advancesinrabiesprophylaxisandtreatmentwithemphasisonimmunoresponsemechanisms |