Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement
Using anterior segment optical coherence tomography (AS-OCT) to compare the depth of corneal demarcation line (DL) after corneal collagen cross-linking (CXL) with subtotal versus customized corneal epithelium debridement. Design: Prospective multi centric case-control study. Materials and Methods...
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| Format: | Article |
| Language: | English |
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university of basrah
2022-12-01
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| Series: | Basrah Journal of Surgery |
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| Online Access: | https://www.iasj.net/iasj/article/256822 |
| _version_ | 1797962907631222784 |
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| author | Salah Zuhair Al-Asadi |
| author_facet | Salah Zuhair Al-Asadi |
| author_sort | Salah Zuhair Al-Asadi |
| collection | DOAJ |
| description | Using anterior segment optical coherence tomography (AS-OCT) to compare the depth of corneal demarcation line (DL) after corneal collagen cross-linking (CXL) with subtotal versus customized corneal epithelium debridement.
Design:
Prospective multi centric case-control study.
Materials and Methods:
The study enrolled 18 patients with bilateral progressive keratoconus. Both eyes treated by CXL using 3 mW/cm2 / 30 minutes setting. One eye with subtotal epithelial debridement ( about 9 mm diameter) and the contralateral eye with customized debridement ( approximately 1 mm single horizontal scratch ). One month postoperatively, patients had AS-OCT imaging to detect and measure the depth of DL.
Results:
Patients’ age mean was 25.17 years +/- 4.81 SD . Epithelial healing completed with in 3-7 days in conventional treatment group and demarcation line was evident in 16 eyes ( 89% ) with a mean depth of 290.31 micro m while in customized epi-off treatment group, the epithelial healing lasted less than 24 hours and DL was detectable in 10 patients ( 55.5 % ) with a mean DL depth of 221 micro m with a statistically significant difference ( p < 0.05 )
Subjective postoperative pain graded as “moderate to severe” in about 77% of eyes underwent 9 mm epi-off CXL compared with 55% of those with customized treatment.
Conclusions:
Although the DL if found in majority cases, but the shallow location in customized corneal debridement cases questioned the efficacy of this technique despite the quick re-epithelialization and less postoperative pain that accompanied it. |
| first_indexed | 2024-04-11T01:20:06Z |
| format | Article |
| id | doaj.art-f8b7125e7bb94d03a0e61ed58d02edca |
| institution | Directory Open Access Journal |
| issn | 1683-3589 2409-501X |
| language | English |
| last_indexed | 2024-04-11T01:20:06Z |
| publishDate | 2022-12-01 |
| publisher | university of basrah |
| record_format | Article |
| series | Basrah Journal of Surgery |
| spelling | doaj.art-f8b7125e7bb94d03a0e61ed58d02edca2023-01-03T14:25:52Zenguniversity of basrahBasrah Journal of Surgery1683-35892409-501X2022-12-01282152010.33762/bsurg.2022.136657.1032Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridementSalah Zuhair Al-AsadiUsing anterior segment optical coherence tomography (AS-OCT) to compare the depth of corneal demarcation line (DL) after corneal collagen cross-linking (CXL) with subtotal versus customized corneal epithelium debridement. Design: Prospective multi centric case-control study. Materials and Methods: The study enrolled 18 patients with bilateral progressive keratoconus. Both eyes treated by CXL using 3 mW/cm2 / 30 minutes setting. One eye with subtotal epithelial debridement ( about 9 mm diameter) and the contralateral eye with customized debridement ( approximately 1 mm single horizontal scratch ). One month postoperatively, patients had AS-OCT imaging to detect and measure the depth of DL. Results: Patients’ age mean was 25.17 years +/- 4.81 SD . Epithelial healing completed with in 3-7 days in conventional treatment group and demarcation line was evident in 16 eyes ( 89% ) with a mean depth of 290.31 micro m while in customized epi-off treatment group, the epithelial healing lasted less than 24 hours and DL was detectable in 10 patients ( 55.5 % ) with a mean DL depth of 221 micro m with a statistically significant difference ( p < 0.05 ) Subjective postoperative pain graded as “moderate to severe” in about 77% of eyes underwent 9 mm epi-off CXL compared with 55% of those with customized treatment. Conclusions: Although the DL if found in majority cases, but the shallow location in customized corneal debridement cases questioned the efficacy of this technique despite the quick re-epithelialization and less postoperative pain that accompanied it.https://www.iasj.net/iasj/article/256822cornea؛collagen cross-linking؛debridement |
| spellingShingle | Salah Zuhair Al-Asadi Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement Basrah Journal of Surgery cornea ؛collagen cross-linking ؛debridement |
| title | Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement |
| title_full | Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement |
| title_fullStr | Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement |
| title_full_unstemmed | Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement |
| title_short | Corneal stromal demarcation line depth after corneal collagen cross-linking following conventional versus customized corneal epithelial debridement |
| title_sort | corneal stromal demarcation line depth after corneal collagen cross linking following conventional versus customized corneal epithelial debridement |
| topic | cornea ؛collagen cross-linking ؛debridement |
| url | https://www.iasj.net/iasj/article/256822 |
| work_keys_str_mv | AT salahzuhairalasadi cornealstromaldemarcationlinedepthaftercornealcollagencrosslinkingfollowingconventionalversuscustomizedcornealepithelialdebridement |