Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance
All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/21/13521 |
| _version_ | 1797467890181472256 |
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| author | Haozhe Zhang Yi Zhou Zengzhen Xing Rajiv Kumar Sah Junqi Hu Hailiang Hu |
| author_facet | Haozhe Zhang Yi Zhou Zengzhen Xing Rajiv Kumar Sah Junqi Hu Hailiang Hu |
| author_sort | Haozhe Zhang |
| collection | DOAJ |
| description | All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy. |
| first_indexed | 2024-03-09T19:00:10Z |
| format | Article |
| id | doaj.art-f8b7486092d8464b92fd60a87934a853 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T19:00:10Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f8b7486092d8464b92fd60a87934a8532023-11-24T05:09:17ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123211352110.3390/ijms232113521Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy ResistanceHaozhe Zhang0Yi Zhou1Zengzhen Xing2Rajiv Kumar Sah3Junqi Hu4Hailiang Hu5Department of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaDepartment of Biochemistry, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinaAll aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.https://www.mdpi.com/1422-0067/23/21/13521androgen metabolismandrogen receptoranti-androgen therapy |
| spellingShingle | Haozhe Zhang Yi Zhou Zengzhen Xing Rajiv Kumar Sah Junqi Hu Hailiang Hu Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance International Journal of Molecular Sciences androgen metabolism androgen receptor anti-androgen therapy |
| title | Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance |
| title_full | Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance |
| title_fullStr | Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance |
| title_full_unstemmed | Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance |
| title_short | Androgen Metabolism and Response in Prostate Cancer Anti-Androgen Therapy Resistance |
| title_sort | androgen metabolism and response in prostate cancer anti androgen therapy resistance |
| topic | androgen metabolism androgen receptor anti-androgen therapy |
| url | https://www.mdpi.com/1422-0067/23/21/13521 |
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