Pharmacological basis of bergapten in gastrointestinal diseases focusing on H+/K+ ATPase and voltage-gated calcium channel inhibition: A toxicological evaluation on vital organs

Pharmacological basis of bergapten in gastrointestinal diseases focusing on H+/K+ ATPase and voltage-gated calcium channel inhibition: A toxicological evaluation on vital organs

Aim and objectives: This study aimed to establish a pharmacological basis for evaluating the effects of bergapten (5-methoxypsoralen) in gastrointestinal diseases and assessment of its toxicological profile.Methods: The pharmacokinetic profile was evaluated using the SwissADME tool. AUTODOCK and PyR...

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Bibliographic Details
Main Authors: Huma Aslam, Arif-ullah Khan, Neelum Gul Qazi, Fawad Ali, Syed Shams ul Hassan, Simona Bungau
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
bergapten
gastroprotective
anti-ulcer
H/K ATPase
calcium channel blocking
acute toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1005154/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1005154/full

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