Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors

Hepatitis D Virus Entry Inhibitors Based on Repurposing Intestinal Bile Acid Reabsorption Inhibitors

Identification of Na<sup>+</sup>/taurocholate co-transporting polypeptide (NTCP) as high-affinity hepatic entry receptor for the Hepatitis B and D viruses (HBV/HDV) opened the field for target-based development of cell-entry inhibitors. However, most of the HBV/HDV entry inhibitors ident...

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Bibliographic Details
Main Authors: Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Dieter Glebe, Karl-Heinz Baringhaus, Joachim Geyer
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Viruses
Subjects:
HBV
HDV
NTCP
ASBT
bile acid transport
entry inhibitor
Online Access:https://www.mdpi.com/1999-4915/13/4/666

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