Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluids
<abstract language="eng">A novel solventless sample preparation, stir-bar sorptive extraction (SBSE), for extraction, and sample enrichment of organic compounds from biological fluids, is described in this manuscript from principle to applications. The SBSE is based on sorptive extra...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Sociedade Brasileira de Química
2008-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700037 |
| _version_ | 1817977213852581888 |
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| author | Andréa Rodrigues Chaves Maria Eugênia Costa Queiroz |
| author_facet | Andréa Rodrigues Chaves Maria Eugênia Costa Queiroz |
| author_sort | Andréa Rodrigues Chaves |
| collection | DOAJ |
| description | <abstract language="eng">A novel solventless sample preparation, stir-bar sorptive extraction (SBSE), for extraction, and sample enrichment of organic compounds from biological fluids, is described in this manuscript from principle to applications. The SBSE is based on sorptive extraction, whereby the compounds are extracted into a polymer coating, polydimethylsiloxane (PDMS), on a magnetic stirring rod. The extraction is controlled by the partitioning coefficient of drugs between the PDMS and sample matrix, and upon the sample-extraction medium phase ratio. The SBSE technique has been applied successfully, with high sensitivities, to biomedical analysis of volatiles and for semi-volatiles drugs from biological sample, including urine, plasma, and saliva. SBSE combined with in situ derivatization, drugs quite more polar (e.g. metabolites) also can be analyzed. |
| first_indexed | 2024-04-13T22:13:52Z |
| format | Article |
| id | doaj.art-f8ba6052c0dc478b84d722a82d29be9f |
| institution | Directory Open Access Journal |
| issn | 0100-4042 1678-7064 |
| language | English |
| last_indexed | 2024-04-13T22:13:52Z |
| publishDate | 2008-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-f8ba6052c0dc478b84d722a82d29be9f2022-12-22T02:27:38ZengSociedade Brasileira de QuímicaQuímica Nova0100-40421678-70642008-01-013171814181910.1590/S0100-40422008000700037Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluidsAndréa Rodrigues ChavesMaria Eugênia Costa Queiroz<abstract language="eng">A novel solventless sample preparation, stir-bar sorptive extraction (SBSE), for extraction, and sample enrichment of organic compounds from biological fluids, is described in this manuscript from principle to applications. The SBSE is based on sorptive extraction, whereby the compounds are extracted into a polymer coating, polydimethylsiloxane (PDMS), on a magnetic stirring rod. The extraction is controlled by the partitioning coefficient of drugs between the PDMS and sample matrix, and upon the sample-extraction medium phase ratio. The SBSE technique has been applied successfully, with high sensitivities, to biomedical analysis of volatiles and for semi-volatiles drugs from biological sample, including urine, plasma, and saliva. SBSE combined with in situ derivatization, drugs quite more polar (e.g. metabolites) also can be analyzed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700037stir-bar sorptive extraction (SBSE)drugsbiological fluids |
| spellingShingle | Andréa Rodrigues Chaves Maria Eugênia Costa Queiroz Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluids Química Nova stir-bar sorptive extraction (SBSE) drugs biological fluids |
| title | Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluids |
| title_full | Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluids |
| title_fullStr | Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluids |
| title_full_unstemmed | Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluids |
| title_short | Extração sortiva em barra de agitação para análise de fármacos em fluidos biológicos Stir-bar sorptive extraction for drugs analysis in biological fluids |
| title_sort | extracao sortiva em barra de agitacao para analise de farmacos em fluidos biologicos stir bar sorptive extraction for drugs analysis in biological fluids |
| topic | stir-bar sorptive extraction (SBSE) drugs biological fluids |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000700037 |
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