A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching
Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entir...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124722003904 |
| _version_ | 1818366502929170432 |
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| author | Fang Luo Wenbin Yang Mingbo Yin Xiaojin Mo Yuhong Pang Chengsong Sun Bingkuan Zhu Wei Zhang Cun Yi Zhidan Li Jipeng Wang Bin Xu Zheng Feng Yangyi Huang Yan Lu Wei Hu |
| author_facet | Fang Luo Wenbin Yang Mingbo Yin Xiaojin Mo Yuhong Pang Chengsong Sun Bingkuan Zhu Wei Zhang Cun Yi Zhidan Li Jipeng Wang Bin Xu Zheng Feng Yangyi Huang Yan Lu Wei Hu |
| author_sort | Fang Luo |
| collection | DOAJ |
| description | Summary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies. |
| first_indexed | 2024-12-13T22:37:11Z |
| format | Article |
| id | doaj.art-f8bb7f236b4d42fca7d407870a122584 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-12-13T22:37:11Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-f8bb7f236b4d42fca7d407870a1225842022-12-21T23:28:57ZengElsevierCell Reports2211-12472022-04-01391110638A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switchingFang Luo0Wenbin Yang1Mingbo Yin2Xiaojin Mo3Yuhong Pang4Chengsong Sun5Bingkuan Zhu6Wei Zhang7Cun Yi8Zhidan Li9Jipeng Wang10Bin Xu11Zheng Feng12Yangyi Huang13Yan Lu14Wei Hu15Shanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology of China Ministry of Health, WHO Collaborating Centre for Tropical Diseases, Joint Research Laboratory of Genetics and Ecology on Parasite-host Interaction, Chinese Center for Disease Control and Prevention and Fudan University, Shanghai, ChinaBiomedical Pioneering Innovation Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology of China Ministry of Health, WHO Collaborating Centre for Tropical Diseases, Joint Research Laboratory of Genetics and Ecology on Parasite-host Interaction, Chinese Center for Disease Control and Prevention and Fudan University, Shanghai, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology of China Ministry of Health, WHO Collaborating Centre for Tropical Diseases, Joint Research Laboratory of Genetics and Ecology on Parasite-host Interaction, Chinese Center for Disease Control and Prevention and Fudan University, Shanghai, ChinaNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology of China Ministry of Health, WHO Collaborating Centre for Tropical Diseases, Joint Research Laboratory of Genetics and Ecology on Parasite-host Interaction, Chinese Center for Disease Control and Prevention and Fudan University, Shanghai, ChinaBiomedical Pioneering Innovation Center (BIOPIC) and Beijing Advanced Innovation Center for Genomics (ICG), Peking University, Beijing, China; College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, ChinaShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China; Corresponding authorShanghai Institute of Infectious Disease and Biosecurity, State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai, China; National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Key Laboratory of Parasite and Vector Biology of China Ministry of Health, WHO Collaborating Centre for Tropical Diseases, Joint Research Laboratory of Genetics and Ecology on Parasite-host Interaction, Chinese Center for Disease Control and Prevention and Fudan University, Shanghai, China; College of Life Sciences, Inner Mongolia University, Hohhot, China; Corresponding authorSummary: The evolution and adaptation of S. japonicum, a zoonotic parasite that causes human schistosomiasis, remain unclear because of the lack of whole-genome data. We construct a chromosome-level S. japonicum genome and analyze it together with 72 samples representing six populations of the entire endemic region. We observe a Taiwan zoophilic lineage splitting from zoonotic populations ∼45,000 years ago, consistent with the divergent history of their intermediate hosts. Interestingly, we detect a severe population bottleneck in S. japonicum, largely coinciding with human history in Asia during the last glacial maximum. We identify several genomic regions underlying natural selection, including GATAD2A and Lmln, both showing remarkable differentiation among different areas. RNAi knockdown suggests association of GATAD2A with parasite development and infection in definitive hosts, while Lmln relates to the specificity of the intermediate hosts. Our study provides insights into the evolution of S. japonicum and serves as a resource for further studies.http://www.sciencedirect.com/science/article/pii/S2211124722003904CP: Microbiology |
| spellingShingle | Fang Luo Wenbin Yang Mingbo Yin Xiaojin Mo Yuhong Pang Chengsong Sun Bingkuan Zhu Wei Zhang Cun Yi Zhidan Li Jipeng Wang Bin Xu Zheng Feng Yangyi Huang Yan Lu Wei Hu A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching Cell Reports CP: Microbiology |
| title | A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
| title_full | A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
| title_fullStr | A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
| title_full_unstemmed | A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
| title_short | A chromosome-level genome of the human blood fluke Schistosoma japonicum identifies the genomic basis of host-switching |
| title_sort | chromosome level genome of the human blood fluke schistosoma japonicum identifies the genomic basis of host switching |
| topic | CP: Microbiology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124722003904 |
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