Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains
Carried out has been comparative assessment between the performances of liquid nutrient pancreatic fibrin overcook-based and bakery yeast autolyzate-based media and conventionally used in manufacturing of cholera vaccine media for submerged cultivation of Vibrio cholerae 569B and V. cholerae M-41 st...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2015-03-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/213 |
| _version_ | 1797220913130766336 |
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| author | A. K. Nikiforov M. V. Antonycheva O. A. Volokh S. A. Eremin M. N. Kireev I. M. Zhulidov Yu. A. Aleshina N. G. Avdeeva N. I. Vakhrushina K. I. Kholmatov |
| author_facet | A. K. Nikiforov M. V. Antonycheva O. A. Volokh S. A. Eremin M. N. Kireev I. M. Zhulidov Yu. A. Aleshina N. G. Avdeeva N. I. Vakhrushina K. I. Kholmatov |
| author_sort | A. K. Nikiforov |
| collection | DOAJ |
| description | Carried out has been comparative assessment between the performances of liquid nutrient pancreatic fibrin overcook-based and bakery yeast autolyzate-based media and conventionally used in manufacturing of cholera vaccine media for submerged cultivation of Vibrio cholerae 569B and V. cholerae M-41 strains. Results of investigation of media quality biological predictors (morphological and biochemical property stability, efficacy of biomass and protective antigen accumulation), which are fibrin hydrolyzate and bakery yeast autolyzate-based, suggest the possibility of using them for the production of cholera vaccine. Deployment of inedible raw material-based media in manufacturing of cholera vaccine is a prospective technology in view of reduction of medical-prophylactic preparation costs. Moreover it allows for solving the problem of protein waste-product disposal, which is generated in the process of anti-rabies immunoglobulin manufacturing, thus decreasing ecological impact on the environment. |
| first_indexed | 2024-03-08T13:44:00Z |
| format | Article |
| id | doaj.art-f8bd4cdad1094b17a64303f1310a192f |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:57:05Z |
| publishDate | 2015-03-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-f8bd4cdad1094b17a64303f1310a192f2024-04-05T16:47:10ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2015-03-0101858810.21055/0370-1069-2015-1-85-88213Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio StrainsA. K. Nikiforov0M. V. Antonycheva1O. A. Volokh2S. A. Eremin3M. N. Kireev4I. M. Zhulidov5Yu. A. Aleshina6N. G. Avdeeva7N. I. Vakhrushina8K. I. Kholmatov9Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Russian Research Anti-Plague Institute “Microbe”Carried out has been comparative assessment between the performances of liquid nutrient pancreatic fibrin overcook-based and bakery yeast autolyzate-based media and conventionally used in manufacturing of cholera vaccine media for submerged cultivation of Vibrio cholerae 569B and V. cholerae M-41 strains. Results of investigation of media quality biological predictors (morphological and biochemical property stability, efficacy of biomass and protective antigen accumulation), which are fibrin hydrolyzate and bakery yeast autolyzate-based, suggest the possibility of using them for the production of cholera vaccine. Deployment of inedible raw material-based media in manufacturing of cholera vaccine is a prospective technology in view of reduction of medical-prophylactic preparation costs. Moreover it allows for solving the problem of protein waste-product disposal, which is generated in the process of anti-rabies immunoglobulin manufacturing, thus decreasing ecological impact on the environment.https://journal.microbe.ru/jour/article/view/213питательная средагидролизат фибринаавтолизат пекарских дрожжейвакцина холернаяглубинное культивированиеnutrient mediumfibrin hydrolyzatebakery yeast autolyzatecholera vaccinesubmerged cultivation |
| spellingShingle | A. K. Nikiforov M. V. Antonycheva O. A. Volokh S. A. Eremin M. N. Kireev I. M. Zhulidov Yu. A. Aleshina N. G. Avdeeva N. I. Vakhrushina K. I. Kholmatov Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains Проблемы особо опасных инфекций питательная среда гидролизат фибрина автолизат пекарских дрожжей вакцина холерная глубинное культивирование nutrient medium fibrin hydrolyzate bakery yeast autolyzate cholera vaccine submerged cultivation |
| title | Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains |
| title_full | Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains |
| title_fullStr | Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains |
| title_full_unstemmed | Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains |
| title_short | Development of Food-Raw-Material-Based Nutrient Media for Submerged Cultivation of Cholera Vibrio Strains |
| title_sort | development of food raw material based nutrient media for submerged cultivation of cholera vibrio strains |
| topic | питательная среда гидролизат фибрина автолизат пекарских дрожжей вакцина холерная глубинное культивирование nutrient medium fibrin hydrolyzate bakery yeast autolyzate cholera vaccine submerged cultivation |
| url | https://journal.microbe.ru/jour/article/view/213 |
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